Results 71 to 80 of about 2,455 (143)

Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis [PDF]

Pharmacogenetics in psychiatry may have benefits for medication treatment success. However, medication regimes leading to drug-drug interactions and potential phenoconversion of actionable pharmacogenetic phenotypes challenge the application of ...
Cahn, Wiepke, Simons, Claudia J.P., van Amelsvoort, Thérèse, van Westrhenen, Roos, Veling, Wim, de Haan, Lieuwe, Leibold, Nicole K.; id_orcid, Alizadeh, Behrooz Z., van der Pluijm, Marieke, van Os, Jim, De Brabander, Emma Y.; id_orcid   +10 more
core   +3 more sources

Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion. [PDF]

, 2016
Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in multiple cell types and or animal models.
Jill A Macoska, Mehrnaz Gharaee-Kermani, Bethany B Moore   +2 more
core   +1 more source

Table1_Pharmacogenetics and phenoconversion: the influence on side effects experienced by psychiatric patients.DOCX

, 2023
Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Kay R. Wagelaar (16881435), Ingeborg Wilting, Wiepke Cahn (155467), Kay R. Wagelaar, Ingeborg Wilting (11578330), Hannelotte W. Hut, Vera H. M. Deneer (10029386), Hannelotte W. Hut (16881432), Manon G. den Uil, Manon G. den Uil (16881429), Vera H. M. Deneer, Heshu Abdullah-Koolmees (10029377), Heshu Abdullah-Koolmees, Wiepke Cahn   +13 more
core   +1 more source

Assessing user perspectives on clinical pharmacogenomics consultation documentation: a user-centered evaluation

Frontiers in Pharmacology
The University of Florida Health Precision Medicine Program plays a crucial role in delivering pharmacogenomics (PGx) result notes to providers who request PGx testing.
Nina Desai, Namratha Ravindra, Bradley Hall, Hana Al Alshaykh, Hana Al Alshaykh, Lauren Lemke, Eda Eken, Emily J. Cicali, Kristin Wiisanen, Larisa H. Cavallari, Khoa A. Nguyen   +10 more
doaj   +1 more source

Nigro-striatal deficits capture phenoconversion risk in isolated REM sleep behavior disorder

Isolated rapid eye movement sleep behavior disorder (iRBD) is characterized by nigro-striatal deficits, comprising dopaminergic denervation of the striatum and loss of dopaminergic cells in the substantia nigra (SN), that may herald phenoconversion to ...
Aurélie Kas, Romain Valabrègue, Stéphane Lehéricy, Jean-Cristophe Corvol, Nicolas Villain, Alexis Baron, Marie Vidailhet, Graziella Mangone, Isabelle Arnulf, Martin Johansson, Pauline Dodet, Vineeth Radhakrishnan, Rahul Gaurav, Anthony Ruze   +13 more
core   +1 more source

Longitudinal plasma proteomics predict phenoconversion to clinically manifest ALS

The study of pre-symptomatic amyotrophic lateral sclerosis (ALS) and the design of disease prevention trials are greatly hampered by our inability to predict which unaffected carriers of ALS-associated pathogenic variants will phenoconvert to clinically ...
Michael P. McDermott, Johnathan Cooper-Knock, Yindi Li, Maria Catalina Fernandez, Ximing Ran, Christina M. Lill, Elizabeth Lin, Nathan Carberry, Volkan Granit, Danielle Colato, Michael Benatar, Zhaohui S. Qin, Joanne Wuu, Anne-Laure Grignon, Paolo Piazza, Andrea Malaspina   +15 more
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Case Report: Severe SIADH and QTc prolongation induced by escitalopram-quetiapine interaction in a CYP2C19 intermediate metabolizer at therapeutic doses

Frontiers in Pharmacology
Escitalopram is widely regarded as a well-tolerated selective serotonin reuptake inhibitor (SSRI) with a favorable safety profile. However, severe adverse events can occur even at therapeutic doses in susceptible individuals.
Zongchen Jiang, Xiaoyu Qu, Zimin Yan, Jungang Fang, Jin Lan, Xin Zhao, Wensheng Qi   +6 more
doaj   +1 more source

Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study

npj Parkinson's Disease
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain.
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Francesco Famà, Andrea Brugnolo, Federico Massa, Agostino Chiaravalloti, Mariana Fernandes, Matteo Spanetta, Fabio Placidi, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Jee-Young Lee, Claudio Liguori, Dario Arnaldi   +19 more
doaj   +1 more source

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation

Scientific Reports, 2018
Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano, José Rodríguez-Nieves, Cory Colaneri, Justin Cotellessa, Diego Almanza, Alisa Zhilin-Roth, Todd Riley, Jill Macoska   +7 more
doaj   +1 more source

Signaling Mechanisms Regulating Fibroblast Activation, Phenoconversion and Fibrosis in the Heart

, 2014
476-482Cardiac fibroblasts (CFs) maintain the cardiac extracellular matrix (ECM) through myocardial remodelling. The remodelling process can become dysregulated during various forms of heart disease which leads to an overall accumulation of ECM. This
Pasumarthi, Kishore B S, MacLean, Jessica   +1 more
core