Results 71 to 80 of about 2,663 (168)

Neurofilament Light Chain and Mutant Huntingtin Across Huntington's Disease Integrated Staging System Stages in Huntington Disease: A Cross‐Sectional Multimodal Analysis

Movement Disorders, EarlyView.
Abstract Background The Huntington's Disease Integrated Staging System (HD‐ISS) provides a framework for staging HD but does not incorporate fluid biomarkers. Objective The aim of this study was to examine neurofilament light chain (NfL) and mutant huntingtin (mHTT) and total tau across HD‐ISS stages and their associations with genetic burden ...
Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Arnau Puig Davi, Rocío Pérez González, Jordi Pegueroles, Andrea Horta‐Barba, Anna Vázquez Oliver, Elisa Rivas Asensio, Daniel Alcolea, Juan Fortea, Marina Guasch‐Jiménez, Tomas Xuclà Ferrarons, Frederic Sampedro Santaló, Lidia Bojtos, Óscar López‐Lombardía, Ignacio Aracil‐Bolaños, Berta Pascual‐Sedano, Carla Franch Martí, Laura Pérez Carasol, Margarita Rubio Romera, Yi Ji, Alexandre Gironell, Antonia Campolongo, Raul Martínez‐Fernández, Alberto Lleó, Javier Pagonabarraga, Saul Martínez‐Horta, Jaime Kulisevsky, BCN‐HD Working Group;, HDClarity investigators, Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Arnau Puig‐Davi, Carla Franch, Paula Arranz‐Horno, Oscar López‐Lombardía, Lidia Bojtos, Antonia Campolongo, Javier Pagonabarraga, Jaime Kulisevsky, Asunción Ávila, Nuria Caballol, Alejandro Peral, Jesús Ruíz‐Idiago, Misericordia Floriach, Matilde Calopa, Helena Bejr Kasem, Clara Marzal Espí, Esteban Muñoz, Celia Painous, Irene Navalpotro, Victor Puente, Victoria González, Pau Pastor, Dolores Vilas, Iñigo Ruiz Barrio, Lourdes Ispierto, Eliot Gómez‐López, Claustre Pons, Gracia Pons, Maria Teresa Buongiorno, Anna Mas, Maria Pilar Gil, Jordi Casanovas, Edward Wild, Tiago Mestre, Mark Guttman, Philippe Rizek, Blair Leavitt, Carsten Saft, Bjorn Falkenburger, Juergen Winkler, Ralf Reilmann, Jan Lewerenz, Alzbeta Mühlbäck, Jesús Pérez‐Pérez, Tamara Fernandez Valle, José Luis López‐Sendón Moreno, Christophe Verny, Cyril Goizet, Caterina Mariotti, Ferdinando Squitieri, Tim Anderson, Richard Roxburgh, Grzegorz Witkowski, Leonor Correia Guedes, Hugh Rickards, Elizabeth Coulthard, Roger Barker, Anne Rosser, Tim Harrower, Robert Thompson, James Herron, Jeremy Cosgrove, Rhys Davies, Nayana Lahiri, Richard Armstrong, Daniel Lashley, Jee Bang, Erin Furr‐Stimming, Jessica Tate, Meagen Salinas, Karen Anderson, Amy Brown   +104 more
wiley   +1 more source

Autophagy in phenoconversion of differentiated and undifferentiated fibroblasts

The FASEB Journal, 2013
Cardiac fibroblasts phenoconvert to hypersecretory myofibroblasts and deposit matrix resulting in cardiac fibrosis and autophagy that is associated to fibroproliferative events. Autophagy inhibition was studied in both primary (P0) rat cardiac fibroblasts (PF) and mouse embryonic fibroblasts (MEF).
Shivika Gupta, Morvarid Kavosh, Shu‐Ru Chen, Saeid Ghavami, Sunil Rattan, Thomas Klonisch, Ian Dixon   +6 more
openaire   +1 more source

Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study [PDF]

The study of pre-symptomatic amyotrophic lateral sclerosis (ALS) and the design of disease prevention trials are greatly hampered by our inability to predict which unaffected carriers of ALS-associated pathogenic variants will phenoconvert to clinically ...
Piazza, Paolo, Ran, Ximing, Cooper-Knock, Johnathan, Colato, Danielle, Fernandez, Maria Catalina, Granit, Volkan, Benatar, Michael, Wuu, Joanne, Li, Yindi, Grignon, Anne-Laure, Lill, Christina M, Malaspina, Andrea, Lin, Eliza, Qin, Zhaohui S, Carberry, Nathan   +14 more
core   +1 more source

Regional Mitochondrial Density Maps Selective Posterior Atrophy in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Mitochondrial dysfunction has been implicated in the pathobiology of Parkinson's disease (PD), yet the spatial relationship between regional energetic demand and patterns of neurodegeneration remains poorly understood, limiting mechanistic insight and development of disease‐modifying therapies.
Ajay Konuri, Lachlan Churchill, Jack Anderson, Anna Ignatavicius, Glenda Halliday, Ramon Landin‐Romero, Simon J.G. Lewis, Elie Matar   +7 more
wiley   +1 more source

Habitual Diet, Gut Microbiome Dysbiosis, and α‐Synucleinopathy Conversion in Isolated Rapid Eye Movement (REM) Sleep Behavior Disorder

Movement Disorders, EarlyView.
Abstract Background Accumulating evidence indicates that habitual diet, including plant‐based dietary patterns, is associated with neurodegenerative α‐synucleinopathy risk. However, the role of diet and its correlation with the gut microbiome in prodromal α‐synucleinopathy, specifically among patients with isolated rapid eye movement (REM) sleep ...
Suyi Xie, Yuhua Yang, Shi Tang, Li Zhou, Jing Wang, Joey W.Y. Chan, Brian Or, Ningning Li, Siyi Gong, Zhixuan He, Jianzhang Ni, Yaping Liu, Jihui Zhang, Paul K.S. Chan, Zigui Chen, Sunny Hei Wong, Vincent C.T. Mok, Ngan Yin Chan, Steven W.H. Chau, Yun Kwok Wing, Bei Huang   +20 more
wiley   +1 more source

Autonomic dysfunction and phenoconversion in idiopathic REM sleep behavior disorder

Clinical Autonomic Research, 2020
REM sleep behavior disorder (RBD) is a common finding among patients with synucleinopathies. We aimed to determine the degree of autonomic dysfunction in patients presenting with idiopathic RBD (iRBD), and the predictive value of autonomic dysfunction for phenoconversion to a defined neurodegenerative disease.We searched our electronic medical record ...
Stuart J, McCarter, Tonette L, Gehrking, Erik K, St Louis, Mariana D, Suarez, Bradley F, Boeve, Michael H, Silber, Phillip A, Low, Wolfgang, Singer   +7 more
openaire   +3 more sources

Neuromelanin‐Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson's Disease: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract The neuropathology of Parkinson's disease (PD) is characterized in part by the degeneration of catecholaminergic neurons, particularly dopaminergic neurons in the substantia nigra pars compacta (SNpc) and noradrenergic neurons in the locus coeruleus (LC), yet no validated in vivo biomarker quantifies this process.
Rayo Akande, Thomas Kustermann, Štefan Holiga, Judith Anzures‐Cabrera, Patrik Brundin, Gennaro Pagano   +5 more
wiley   +1 more source

Precision anesthesia and pharmacogenomics: a scoping review of personalized drug response

Frontiers in Anesthesiology
BackgroundAnesthetic agent selection and dosing have historically relied on empirical models without taking into account inter-individual variability in drug response, leading to adverse drug reactions (ADRs).
Sarina Nikzad, Ofelia Loani Elvir-Lazo, Robert Wong   +2 more
doaj   +1 more source

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder

Future Science OA
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Monica Pinoli, Michele Terzaghi, Franca Marino, Cristoforo Comi, Maurizio Versino, Marco Cosentino   +5 more
doaj   +1 more source

Attitudes, Strategies and Value Frameworks Guiding Risk Communication in Isolated REM Behaviour Disorder: A Scoping Review of Perspectives From Patients and Healthcare Professionals

Journal of Sleep Research, EarlyView.
ABSTRACT Idiopathic/isolated REM sleep behaviour disorder (iRBD) is widely recognized as a key prodromal condition associated with a high risk of progression to α‐synucleinopathies. Despite this, disclosure of risk related to such early signs of neurodegeneration remains controversial in clinical practice.
Serena Covino, Ana Borovecki, Marko Ćurković, Laura Adelaide Dalla Vecchia, Beatrice De Maria, Clara Gino, Alessandra Grossi, Mario Picozzi, Davide Sattin, on behalf of the DEEPEN iRBD Consortium   +9 more
wiley   +1 more source