Results 71 to 80 of about 1,862 (162)

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Aging, 2016
Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis.
Fukumoto, Jutaro, Soundararajan, Ramani, Leung, Joseph, Cox, Ruan, Jr., Mahendrasah, Sanjay, Muthavarapu, Neha, Herrin, Travis, Czachor, Alexander, Tan, Lee C., Hosseinian, Nima, Patel, Priyanshi, Gone, Jayanthraj, Breitzig, Mason T., Cho, Young, Cooke, Andrew J., Galam, Lakshmi, Narala, Venkata Ramireddy, Pathak, Yashwant, Lockey, Richard F., Kolliputi, Narasaiah   +19 more
openaire   +3 more sources

Factors associated with phenoconversion of idiopathic rapid eye movement sleep behavior disorder: a prospective study

npj Parkinson's Disease
This study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort.
Yuan Yuan, Yuan Li, Hui Zhang, Yajie Zang, Xiaonan Liu, Yue Hou, Shuqin Zhan, Yanning Cai, Wei Mao, Piu Chan   +9 more
doaj   +1 more source

Assessing user perspectives on clinical pharmacogenomics consultation documentation: a user-centered evaluation

Frontiers in Pharmacology
The University of Florida Health Precision Medicine Program plays a crucial role in delivering pharmacogenomics (PGx) result notes to providers who request PGx testing.
Nina Desai, Namratha Ravindra, Bradley Hall, Hana Al Alshaykh, Hana Al Alshaykh, Lauren Lemke, Eda Eken, Emily J. Cicali, Kristin Wiisanen, Larisa H. Cavallari, Khoa A. Nguyen   +10 more
doaj   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2250-2259, July 2026.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics

Pharmacopsychiatry
Abstract Introduction CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status.
Scherf-Clavel, Maike, Weber, Heike, Unterecker, Stefan, Frantz, Amelie, Eckert, Andreas, Reif, Andreas, Deckert, Jürgen, Hahn, Martina   +7 more
openaire   +2 more sources

Differential Progression of Neuroinflammation in Patients with Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder

Movement Disorders, Volume 41, Issue 7, Page 1893-1898, July 2026.
Abstract Background Neuroinflammation, measured using [11C](R)‐PK11195 positron emission tomography (PET), has been reported in isolated rapid‐eye‐movement sleep behavior disorder (iRBD), but its temporal progression is unknown. Objective The aim was to assess longitudinal progression of neuroinflammation in iRBD patients and its relationship with ...
Andreas Myhre Baun, Alex Iranzo, Miriam Højholt Terkelsen, Rainer Hinz, Morten Gersel Stokholm, Kristian Stær, Mónica Serradel, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Arne Møller, Carles Gaig, Eduardo Tolosa, David J. Brooks, Per Borghammer, Simon Fristed Eskildsen, Nicola Pavese   +17 more
wiley   +1 more source

‘Phenoconversion’ in adult patients with β-thalassemia

, 2023
To the Editor: Patients with clinically significant forms of β-thalassemia have been historically classified as having a β-thalassemia major or β-thalassemia intermedia phenotype, with the first primarily referring to patients who present with severe anemia during early childhood and require lifelong transfusion therapy and the latter relating to ...
Khaled M. Musallam, Susanna Barella, Raffaella Origa, Giovanni Battista Ferrero, Roberto Lisi, Annamaria Pasanisi, Filomena Longo, Barbara Gianesin, Gian Luca Forni, Lucia De Franceschi   +9 more
openaire   +1 more source

Case Report: Severe SIADH and QTc prolongation induced by escitalopram-quetiapine interaction in a CYP2C19 intermediate metabolizer at therapeutic doses

Frontiers in Pharmacology
Escitalopram is widely regarded as a well-tolerated selective serotonin reuptake inhibitor (SSRI) with a favorable safety profile. However, severe adverse events can occur even at therapeutic doses in susceptible individuals.
Zongchen Jiang, Xiaoyu Qu, Zimin Yan, Jungang Fang, Jin Lan, Xin Zhao, Wensheng Qi   +6 more
doaj   +1 more source

Synergistic Effects of Inflammation and Drug Interactions on CYP3A5*3/*3 Phenoconversion in Antipsychotic Metabolism

Pharmaceutics
Background: Traditional genotype-guided dosing often fails to predict real-time variability in the metabolic phenotype during complex polypharmacy.
Krisztina Kőhalmy, Ayaan Borthakur, Pálma Porrogi   +2 more
doaj   +1 more source

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation

Scientific Reports, 2018
Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano, José Rodríguez-Nieves, Cory Colaneri, Justin Cotellessa, Diego Almanza, Alisa Zhilin-Roth, Todd Riley, Jill Macoska   +7 more
doaj   +1 more source