Results 51 to 60 of about 2,455 (143)

Proposed mechanism of action used by CXCL12 to drive myofibroblast phenoconversion.

, 2016
The canonical pathway driving myofibroblast differentiation is driven by TGF-β-mediated Smad and MEK/Erk signaling14. However, upon binding to CXCR4, CXCL12 promotes the transactivation of EGFR, potentially through MMP/ADAM as previously described by ...
Mehrnaz Gharaee-Kermani (118877), Jill A. Macoska (118895), Diego Almanza (3150834), Susan C. Patalano (3150831), José A. Rodríguez-Nieves (3150828)   +4 more
core   +1 more source

Neurologic and psychiatric features of impending neurodegeneration in iRBD

Clinical Parkinsonism & Related Disorders, 2023
Introduction: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is linked to Parkinson’s disease and other alpha-synucleinopathies, but various subsets of iRBD may not carry equal risk (i.e., those with depression are at higher risk than
Daniel A. Barone, Harini Sarva, Natalie Hellmers, Fei Wang, Zhenxing Xu, Ana C. Krieger, Claire Henchcliffe   +6 more
doaj   +1 more source

Dopamine‐Deficiency‐Related Reorganization of the Somatomotor Network in Prodromal and Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Introduction Network attack tolerance (NAT) measures the brain's ability to sustain information flow despite the loss of critical brain regions. In Parkinson's disease (PD), NAT has been linked to cognitive and motor function. However, it remains unclear how dopaminergic degeneration shapes NAT, and whether it relates to motor symptom ...
Adrian L. Asendorf, Verena Dzialas, Thilo van Eimeren, Merle C. Hoenig   +3 more
wiley   +1 more source

Serum Neurofilament Light Chain and GFAP in Amyotrophic Lateral Sclerosis on a Commercial ECLIA Platform

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims In amyotrophic lateral sclerosis (ALS), SIMOA‐based studies show that baseline serum neurofilament light chain (NfL) predicts the revised ALS Functional Rating Scale (ALSFRS‐R) decline rate and survival. The Roche Elecsys electrochemiluminescence immunoassay (ECLIA) reports values approximately six‐fold lower; cross‐platform ...
Nicholas S. Streicher
wiley   +1 more source

Precision medication: An illustrative case series guiding the clinical application of multi‐drug interactions and pharmacogenomics

Clinical Case Reports, 2020
Precision medication entails selecting the precise medication, dose, and timing of administration. Multi‐drug interactions and genetics significantly affect precision medication. In this article, we present two simulated cases for real‐world applications
Kevin T. Bain, David McGain, Emily J. Cicali, Calvin H. Knowlton, Veronique Michaud, Jacques Turgeon   +5 more
doaj   +1 more source

Neurofilament Light Protein Predicts Disease Progression in Idiopathic REM Sleep Behavior Disorder

Journal of Parkinson’s Disease, 2023
Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is increasingly recognized as a manifestation preceding the α-synucleinopathies like Parkinson’s disease (PD).
Xuan Zhang, Li Ma, Danqi Liang, Bingxin Song, Jingshan Chen, Yaqin Huang, Lin Xu, Peng Zhao, Wei Wu, Nan Zhang, Rong Xue   +10 more
doaj   +1 more source

Actigraphy Meets AI: A Digital Biomarker for Parkinson's Disease and Isolated REM Sleep Behaviour Disorder

Journal of Sleep Research, EarlyView.
ABSTRACT Isolated rapid eye movement (REM) sleep behaviour disorder (RBD) is an early stage of alpha‐synucleinopathies, such as Parkinson's disease (PD). Actigraphy is a promising tool for assessing rest‐activity patterns, however its diagnostic or predictive value in these disorders is understudied.
Leonor Lopes, Jan D. Warncke, Irina Filchenko, Kuangyu Shi, Claudio L. A. Bassetti, Carolin Schäfer   +5 more
wiley   +1 more source

Selected health and lifestyle factors, cytosine‐adenine‐guanine status, and phenoconversion in Huntington's disease [PDF]

, 2018
BACKGROUND:In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users.
Biglan, Kevin, Oakes, David, Shoulson, Ira, Tanner, Caroline, Investigators, on behalf of the Huntington Study Group Prospective Huntington At‐Risk Observational Study, Eberly, Shirley, Marder, Karen   +6 more
core   +1 more source

Signaling Mechanisms Underlying Cxcl5-Mediated Fibroblast to Myofibroblast Phenoconversion

, 2017
Lower urinary tract symptoms (LUTS) comprise a number of medical conditions including weak stream, incomplete bladder voiding, and nocturia that affect quality of life and can progress to more severe symptoms if left untreated.
Belford, Timothy K.
core   +1 more source

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source