Results 51 to 60 of about 2,106 (148)

Effects of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacological Effects of Orally Administered Tramadol: A Randomised Controlled Trial

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Tramadol is a widely used analgesic whose bioactivation to O‐desmethyltramadol is primarily mediated by cytochrome P450 2D6 (CYP2D6). Genetic variability and drug–drug interactions affecting CYP2D6 may influence tramadol pharmacokinetics and pharmacological effects.
Tuukka Saarikoski, Teijo I. Saari, Janne T. Backman, Mikko Niemi, Pertti J. Neuvonen, Klaus T. Olkkola, Kari Laine   +6 more
wiley   +1 more source

Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry‐Based Study

Annals of Neurology, Volume 99, Issue 6, Page 1516-1525, June 2026.
Objective The prodromal phase of amyotrophic lateral sclerosis (ALS) is poorly defined. We aimed to characterize prescription drug use patterns in the pre‐diagnostic period by analyzing nationwide prescription data to identify the earliest divergence between individuals who developed ALS and matched healthy controls.
Magne Haugland Solheim, Trond Riise, Marianna Cortese, Ola Nakken, Ole‐Bjørn Tysnes, Jannicke Igland, Kjetil Bjornevik   +6 more
wiley   +1 more source

CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling.

, 2016
Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS).
Mehrnaz Gharaee-Kermani (118877), Jill A Macoska, Susan C Patalano, José A Rodríguez-Nieves, Jill A. Macoska (118895), Diego Almanza (3150834), Susan C. Patalano (3150831), Mehrnaz Gharaee-Kermani, José A. Rodríguez-Nieves (3150828), Diego Almanza   +9 more
core   +1 more source

To know or not to know? Opinions of patients with Parkinson’s Disease on disclosing risk of phenoconversion in RBD

, 2023
Introduction. The aim of our study was to find out the opinion of patients with Parkinson’s Disease (PD) whose disease was preceded by REM sleep behaviour disorder (RBD) regarding early information about the high risk of phenoconversion in RBD.
Gajos, Agata; Department of Extrapyramidal Disorders, Medical University of Lodz, Central University Hospital, Lodz, Bogucki, Andrzej; Department of Extrapyramidal Disorders, Medical University of Lodz, Central University Hospital, Lodz, Kroemeke, Aleksandra; Department of Psychology, SWPS University, Warsaw, Poland, Marcinkowska, Aneta; Department of Extrapyramidal Disorders, Medical University of Lodz, Central University Hospital, Lodz   +3 more
core   +1 more source

High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis

Annals of Neurology, Volume 99, Issue 6, Page 1502-1515, June 2026.
Objective SOD1 is the second most frequently mutated gene in European patients with amyotrophic lateral sclerosis (ALS). Given the recent authorization of SOD1‐targeted antisense oligonucleotides for SOD1‐ALS, prompt screening for SOD1 mutations in patients with ALS patients is highly recommended.
Delia Gagliardi, Chiara Villella, Matteo Zanovello, Virginia Iacobelli, Stefania Corti, Giacomo Pietro Comi, Pietro Fratta, Henry Houlden, Arianna Tucci, Dario Ronchi   +9 more
wiley   +1 more source

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Aging, 2016
Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis.
Fukumoto, Jutaro, Soundararajan, Ramani, Leung, Joseph, Cox, Ruan, Jr., Mahendrasah, Sanjay, Muthavarapu, Neha, Herrin, Travis, Czachor, Alexander, Tan, Lee C., Hosseinian, Nima, Patel, Priyanshi, Gone, Jayanthraj, Breitzig, Mason T., Cho, Young, Cooke, Andrew J., Galam, Lakshmi, Narala, Venkata Ramireddy, Pathak, Yashwant, Lockey, Richard F., Kolliputi, Narasaiah   +19 more
openaire   +3 more sources

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, Volume 41, Issue 5, Page 1299-1303, May 2026.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis [PDF]

Pharmacogenetics in psychiatry may have benefits for medication treatment success. However, medication regimes leading to drug-drug interactions and potential phenoconversion of actionable pharmacogenetic phenotypes challenge the application of ...
Cahn, Wiepke, Simons, Claudia J.P., van Amelsvoort, Thérèse, van Westrhenen, Roos, Veling, Wim, de Haan, Lieuwe, Leibold, Nicole K.; id_orcid, Alizadeh, Behrooz Z., van der Pluijm, Marieke, van Os, Jim, De Brabander, Emma Y.; id_orcid   +10 more
core   +2 more sources

Phenoconversion: Drug-Drug-Gene Interactions

, 2019
Based on the extensive, poor, intermediate and ultrarapid phenotypes of patients, inferences may be made relative to drug metabolism, ultimately leading to changes in therapeutic drug choice or dosing.
Kulp, Molly, Kisor, David F., Marlowe, Brooke, Roberson, Taylor, Limberg, Emily   +4 more
core  

Spoken language alterations can predict phenoconversion in isolated REM sleep behavior disorder: a multicentric study.

, 2023
OBJECTIVE This study assessed the relationship between speech and language impairment and outcome in a multicenter cohort of isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD).
Dušek, Petr, Škrabal, Dominik, Dauvilliers, Yves, Postuma, Ronald, Evangelista, Elisa, Montplaisir, Jacques, St. Louis, Erik, Hlavnička, Jan, Gagnon, Jean‐françois, Tykalová, Tereza, Rusz, Jan, Postuma, Ronald B, Gagnon, Jean-François, Růžička, Evžen, Heim, Beatrice, Šonka, Karel, Timm, Paul, Šubert, Martin, Pelletier, Amelie, Stefani, Ambra, Teigen, Luke, Janzen, Annette, Marelli, Sara, Novotný, Michal, Oertel, Wolfgang, Ferini-Strambi, Luigi, Högl, Birgit, Teigen, Luke N, Timm, Paul C, Galbiati, Andrea, St Louis, Erik K, Holzknecht, Evi   +31 more
core   +1 more source