Results 1 to 10 of about 94,701 (219)

Excipient knowledgebase: Development of a comprehensive tool for understanding the disposition and interaction potential of common excipients

CPT: Pharmacometrics & Systems Pharmacology, 2021
Although the use of excipients is widespread, a thorough understanding of the drug interaction potential of these compounds remains a frequent topic of current research.
Savannah J. McFeely, Jingjing Yu, Yan Wang, Cheryl Wu, Isabelle Ragueneau‐Majlessi   +4 more
doaj   +1 more source

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan

Pharmaceuticals, 2021
Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility.
Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar, Suresh Bandari, Dong Wuk Kim   +5 more
doaj   +1 more source

Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice

Pharmaceutics, 2021
This study aims to investigate the effect of lactic acid bacteria (LAB) on in vitro and in vivo metabolism and the pharmacokinetics of ginsenosides in mice.
Ji-Hyeon Jeon, Jaehyeok Lee, Jin-Hyang Park, Chul-Haeng Lee, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance

Pharmaceutics, 2021
Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability.
Surendra Poudel, Dong Wuk Kim
doaj   +1 more source

Adapting regulatory drug‐drug interaction guidance to design clinical pharmacokinetic natural product‐drug interaction studies: A NaPDI Center recommended approach

Clinical and Translational Science, 2022
Pharmacokinetic drug interactions precipitated by botanical and other natural products (NPs) remain critically understudied. Investigating these complex interactions is fraught with difficulties due to the methodologic and technical challenges associated
Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine   +5 more
doaj   +1 more source

Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fimasartan, Amlodipine, and Hydrochlorothiazide, in Rats Using LC-MS/MS and Subsequent Application to Pharmacokinetic Drug Interaction with Red Ginseng Extract

Toxics, 2022
Fimasartan, amlodipine, and hydrochlorothiazide are commonly used in combination therapies as antihypertensive drugs. This study aimed to develop and validate an analytical method for fimasartan, its active and major metabolite fimasartan-amide ...
So-Yeon Jeon, Ji-Hyeon Jeon, Jin-Hyang Park, Jihoon Lee, Minyeong Pang, Min-Koo Choi, Im-Sook Song   +6 more
doaj   +1 more source

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

Pharmaceutics, 2021
We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin ...
Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park, Min-Koo Choi   +4 more
doaj   +1 more source

Fabrication of Gastro-Floating Famotidine Tablets: Hydroxypropyl Methylcellulose-Based Semisolid Extrusion 3D Printing

Pharmaceutics, 2023
Semisolid extrusion (SSE) three-dimensional (3D) printing uses drug-loaded paste for the printing process, which is capable of constructing intricate 3D structures.
Hyun Seok Yang, Dong Wuk Kim
doaj   +1 more source

Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions

Clinical and Translational Science, 2020
As the research into the organic anion transporting polypeptides (OATPs) continues to grow, it is important to ensure that the data generated are accurate and reproducible.
Savannah J. McFeely, Tasha K. Ritchie, Isabelle Ragueneau‐Majlessi   +2 more
doaj   +1 more source

Assessment of potential drug interactions among psychiatric inpatients receiving antipsychotic therapy of a secondary care hospital, United Arab Emirates

Journal of Advanced Pharmaceutical Technology & Research, 2021
The majority of the antipsychotic drugs are also known to interact with other co-administered drugs. Drug–drug interaction (DDI) reports among patients receiving antipsychotic medications are common.
Haneen A. R. Aburamadan, Sathvik Belagodu Sridhar, Talaat Matar Tadross   +2 more
doaj   +1 more source