Results 11 to 20 of about 2,242,237 (349)

LLM-Enhanced Multimodal Framework for Drug–Drug Interaction Prediction [PDF]

Biomedicines
Background: Drug–drug interactions (DDIs) involve pharmacokinetic or pharmacodynamic changes that occur when multiple drugs are co-administered, potentially leading to reduced efficacy or adverse effects.
Song Im, Younhee Ko
doaj   +2 more sources

MDG-DDI: multi-feature drug graph for drug-drug interaction prediction [PDF]

BMC Bioinformatics
Background Drug–drug interactions (DDIs) frequently occur in combination therapy and may cause adverse effects or reduced efficacy. Existing computational approaches often fail to capture both the semantic information in drug sequences and the structural
Wenjun Li, Yiting Zhou, Wanjun Ma, Weijun Liang, Xiwei Tang   +4 more
doaj   +2 more sources

Graph neural network-based drug-drug interaction prediction [PDF]

Scientific Reports
With the growing variety of pharmacological compounds and the increasing need for polypharmacy, accurately predicting drug-drug interactions (DDIs) is essential to ensure both treatment efficacy and patient safety. Beneficial DDIs can enhance therapeutic
Khushnood Abbas, Chen Hao, Xu Yong, Mohammad Kamrul Hasan, Shayla Islam, Abdul Hadi Abd Rahman   +5 more
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Preclinical Pharmacokinetics, ADME, and Drug-Drug Interaction Evaluation of S024, a Novel p38/MK2 Inhibitor for Rheumatoid Arthritis [PDF]

Drug Design, Development and Therapy
Qianlei Ye,1,2,* Wei Xing,2,* Xuefeng Hu,2 Wenjuan Liu,2 Jigang Wu,2 Hailan Huang,2 Ying Xiao,2 Yanjun Hong1 1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Shenzhen, People’s Republic of China; 2Shenzhen Salubris ...
Ye Q, Xing W, Hu X, Liu W, Wu J, Huang H, Xiao Y, Hong Y   +7 more
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Excipient knowledgebase: Development of a comprehensive tool for understanding the disposition and interaction potential of common excipients

CPT: Pharmacometrics & Systems Pharmacology, 2021
Although the use of excipients is widespread, a thorough understanding of the drug interaction potential of these compounds remains a frequent topic of current research.
Savannah J. McFeely, Jingjing Yu, Yan Wang, Cheryl Wu, Isabelle Ragueneau‐Majlessi   +4 more
doaj   +1 more source

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan

Pharmaceuticals, 2021
Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility.
Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar, Suresh Bandari, Dong Wuk Kim   +5 more
doaj   +1 more source

NOACs: drug–drug interactions [PDF]

Canadian Medical Association Journal, 2016
We commend Fralick and colleagues for their article on drug interactions with rivaroxaban.[1][1] All novel oral anticoagulants (NOACs) were introduced as at least noninferior (in some cases superior) to warfarin.
Bartosz, Hudzik, Andrzej, Lekston, Mariusz, Gasior   +2 more
openaire   +2 more sources

Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice

Pharmaceutics, 2021
This study aims to investigate the effect of lactic acid bacteria (LAB) on in vitro and in vivo metabolism and the pharmacokinetics of ginsenosides in mice.
Ji-Hyeon Jeon, Jaehyeok Lee, Jin-Hyang Park, Chul-Haeng Lee, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance

Pharmaceutics, 2021
Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability.
Surendra Poudel, Dong Wuk Kim
doaj   +1 more source

Adapting regulatory drug‐drug interaction guidance to design clinical pharmacokinetic natural product‐drug interaction studies: A NaPDI Center recommended approach

Clinical and Translational Science, 2022
Pharmacokinetic drug interactions precipitated by botanical and other natural products (NPs) remain critically understudied. Investigating these complex interactions is fraught with difficulties due to the methodologic and technical challenges associated
Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine   +5 more
doaj   +1 more source