Results 61 to 70 of about 7,761,768 (249)

Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Frontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current treatment plan is the administration of multiple medications.
Archana Balasubramanian, Raksha Sudarshan, Jhinuk Chatterjee   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Novel network pharmacology methods for drug mechanism of action identification, pre-clinical drug screening and drug repositioning [PDF]

, 2011
The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Here we present two methodology innovations on network pharmacology modeling.
Jianghui Xiong
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Drug–gene and drug–drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial

, 2019
Background: Tramadol and codeine are metabolized by CYP2D6 and are subject to drug-gene and drug-drug interactions. Methods: This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine while ...
Decker, Brian S., Zang, Yong, Pratt, Victoria M., Skaar, Todd C., Holmes, Ann M., Eadon, Michael T., Zhang, Yifei, Gufford, Brandon T., Dexter, Paul R., Rosenman, Marc B., Fulton, Cathy R., Desta, Zeruesenay, Callaghan, John T., Levy, Kenneth D.   +13 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Impact of study design and statistical model in pharmacogenetic studies with gene‐treatment interaction

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gene‐treatment interactions, just like drug‐drug interactions, can have dramatic effects on a patient response and therefore influence the clinician decision at the patient’s bedside.
Camille Couffignal, France Mentré, Julie Bertrand   +2 more
doaj   +1 more source

DRUGPATH: The Drug Gene Pathway Meta-Database

, 2020
The complexity of modern-day diseases often requires drug treatment therapies consisting of multiple pharmaceutical interventions, which can lead to adverse drug reactions for patients.
Rajeev Jaundoo, Craddock, Travis J A, Travis J. A. Craddock, Jaundoo, Rajeev   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Drug repositioning using drug-disease vectors based on an integrated network

BMC Bioinformatics, 2018
Background Diverse interactions occur between biomolecules, such as activation, inhibition, expression, or repression. However, previous network-based studies of drug repositioning have employed interaction on the binary protein-protein interaction (PPI)
Taekeon Lee, Youngmi Yoon
doaj   +1 more source