Results 51 to 60 of about 7,761,768 (249)

A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes

Frontiers in Genetics, 2014
New approaches to toxicity testing have incorporated high-throughput screening across a broad-range of in vitro assays to identify potential key events in response to chemical or drug treatment.
Oscar Takeo Suzuki, Amber eFrick, Bethany B Parks, O. Joseph eTrask Jr., Natasha eButz, Brian eSteffy, Emmanuel eChan, David K Scoville, Eric eHealy, Cristina eBenton, Patricia E McQuaid, Russell S Thomas, Tim eWiltshire   +12 more
doaj   +1 more source

Comparing methods for drug–gene interaction prediction on the biomedical literature knowledge graph: performance versus explainability

BMC Bioinformatics, 2023
This paper applies different link prediction methods on a knowledge graph generated from biomedical literature, with the aim to compare their ability to identify unknown drug-gene interactions and explain their predictions.
Fotis Aisopos, Georgios Paliouras
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition

Computational and Structural Biotechnology Journal, 2020
In recent decades the identification of pharmacogenomic gene-drug associations has evolved tremendously. Despite this progress, a major fraction of the heritable inter-individual variability remains elusive.
Yitian Zhou, Volker M. Lauschke
doaj   +1 more source

gene-fam-with-drug-target

, 2016
data for Fig.5: gene-fam-with-drug-target.txt column 1: HGNC gene family ID or name column 2: number of drug target genes (gene products) in the (HGNC) gene family column 3: number of genes in the (HGNC) gene family (possibly including pseudogenes ...
Wentian Li (28857), Pedro Miramontes (373939), Miramontes, Pedro, Oscar Fontanelli (3133830), Li, Wentian, Fontanelli, Oscar   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Metabolic Syndrome Drug Therapy: The Potential Interplay of Pharmacogenetics and Pharmacokinetic Interactions in Clinical Practice: A Narrative Review

Diabetology
Metabolic syndrome (MetS) presents a significant global health challenge, characterized by a cluster of metabolic alterations including obesity, hypertension, insulin resistance/dysglycemia, and atherogenic dyslipidemia.
Sandra Knežević, Francesca Filippi-Arriaga, Andrej Belančić, Tamara Božina, Jasenka Mršić-Pelčić, Dinko Vitezić   +5 more
doaj   +1 more source

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Journal of Pharmacy and Bioallied Sciences, 2014
Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules.
Kanika Madaan, Sandeep Kumar, Neelam Poonia, Viney Lather, Deepti Pandita   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling for the Prediction of CYP2D6‐Mediated Gene–Drug–Drug Interactions

CPT: Pharmacometrics & Systems Pharmacology, 2019
The aim of this work was to predict the extent of Cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interactions (DDIs) in different CYP2D6 genotypes using physiologically‐based pharmacokinetic (PBPK) modeling. Following the development of a new duloxetine
Flavia Storelli, Jules Desmeules, Youssef Daali   +2 more
doaj   +1 more source