Results 51 to 60 of about 7,431,159 (264)

Pharmacological approach to Drug and Drug-Food Interactions [PDF]

, 2023
Medication interactions must be taken into consideration in order to avoid toxicities, side effects, and lower efficacy brought on by subtherapeutic drug doses.
Hasan, Fatima
core  

Potential drug interactions : exposure and management in hospital and ambulatory settings [PDF]

, 2006
Health care professionals are responsible to ensure safe dispensing and use of drug regimens involving the use of drug combinations that may interact and cause serious adverse events.
Indermitte, Jörg Lorenz
core   +1 more source

Drug–Drug–Gene Interactions in Cardiovascular Medicine

Pharmacogenomics and Personalized Medicine, 2022
Innocent G Asiimwe, Munir Pirmohamed The Wolfson Centre for Personalized Medicine, MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool ...
Asiimwe IG, Pirmohamed M
doaj  

Learning Petri net models of non-linear gene interactions [PDF]

, 2005
Understanding how an individual's genetic make-up influences their risk of disease is a problem of paramount importance. Although machine-learning techniques are able to uncover the relationships between genotype and disease, the problem of automatically
Mayo, Michael
core   +1 more source

Utilizing Large Electronic Medical Record Data Sets to Identify Novel Drug–Gene Interactions for Commonly Used Drugs

Clinical pharmacology and therapy, 2021
Real‐world prescribing of drugs differs from the experimental systems, physiological‐pharmacokinetic models, and clinical trials used in drug development and licensing, with drugs often used in patients with multiple comorbidities with resultant ...
M. Malki, A. Dawed, C. Hayward, A. Doney, E. Pearson   +4 more
semanticscholar   +1 more source

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M.   +26 more
core   +1 more source

Predicting Potential Drug-Drug-Gene Interactions in a Population of Individuals Utilizing a Community-Based Pharmacy

CNS Spectrums, 2022
Introduction Adverse drug reactions (ADRs) are associated with increased morbidity, mortality, and resource utilization. Drug interactions (DDIs) are among the most common causes of ADRs, and estimates have cited that up to 22% of patients take ...
D. Dowd, Gabriela Williams, David S Krause, Stephen J. Clarke, Eric Crumbaugh, J. Botbyl, Stephen R Saklad   +6 more
semanticscholar   +1 more source

Expression of drug transporters in intestine and blood [PDF]

, 2005
Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core   +1 more source

Xprediction: Explainable EGFR-TKIs response prediction based on drug sensitivity specific gene networks.

PLoS ONE, 2022
In recent years, drug sensitivity prediction has garnered a great deal of attention due to the growing interest in precision medicine. Several computational methods have been developed for drug sensitivity prediction and the identification of related ...
Heewon Park, Rui Yamaguchi, Seiya Imoto, Satoru Miyano   +3 more
doaj   +1 more source