Results 71 to 80 of about 7,761,768 (249)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

HCDT 2.0: A Highly Confident Drug-Target Database for Experimentally Validated Genes, RNAs, and Pathways

Scientific Data
Drug-target interactions constitute the fundamental basis for understanding drug action mechanisms and advancing therapeutic discovery. While existing drug-target databases have contributed valuable resources, they exhibit structural and functional ...
Xinying Liu, Dehua Feng, Jiaqi Chen, Tianyi Li, Xuefeng Wang, Ruijie Zhang, Jian Chen, Xingjun Cai, Huirui Han, Lei Yu, Xia Li, Bing Li, Limei Wang, Jin Li   +13 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms [PDF]

Brazilian Journal of Pharmaceutical Sciences
Hydroxychloroquine (HCQ) is a chiral drug used to treat malaria and inflammatory diseases, available as a racemic mixture of R-and S-HCQ. This work aimed to build physiologically-based pharmacokinetic (PBPK) models to predict the pharmacokinetics (PK) of
Gabriella de Souza Gomes Ribeiro, Leandro Francisco Pippa, Fernanda de Lima Moreira, Natália Valadares de Moraes   +3 more
doaj   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M., Kaufmann, Michel R, Gnerre, Carmella, Looser, Renate, Blättler, Sharon, Oscarson, Mikael, Handschin, Christoph, Meyer, Urs A, Roth, Adrian, Podvinec, Michael   +35 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

MiDNE a tool for Multi-omics genes and drugs interactions discovery

Computational and Structural Biotechnology Journal
The availability of models representing molecular interactions in complex pathologies is essential for understanding their molecular setup and identifying therapeutic vulnerabilities.
Aurora Brandi, Barbara Majello, Ines Simeone, Massimiliano Romano, Michele Ceccarelli, Giovanni Scala   +5 more
doaj   +1 more source

Predicting Drug–Gene–Disease Associations by Tensor Decomposition for Network-Based Computational Drug Repositioning

, 2023
Drug repositioning offers the significant advantage of greatly reducing the cost and time of drug discovery by identifying new therapeutic indications for existing drugs.
Young-Rae Cho, Yoonbee Kim
core   +1 more source

Towards personalized management of drug interactions: from drug-drug-interaction to drug-drug-gene-interaction [PDF]

, 2020
Drug-drug interactions (DDIs) are still an important contributor to ineffective treatment or deleterious side effects. Therefore, assessing the prevalence and clinical relevance of frequently observed potential DDIs is an important step towards improving
Bahar, Akbar
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source