Results 71 to 80 of about 7,431,159 (264)

Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Frontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current treatment plan is the administration of multiple medications.
Archana Balasubramanian, Raksha Sudarshan, Jhinuk Chatterjee   +2 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]

, 2005
The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
core   +1 more source

Metabolic Syndrome Drug Therapy: The Potential Interplay of Pharmacogenetics and Pharmacokinetic Interactions in Clinical Practice: A Narrative Review

Diabetology
Metabolic syndrome (MetS) presents a significant global health challenge, characterized by a cluster of metabolic alterations including obesity, hypertension, insulin resistance/dysglycemia, and atherogenic dyslipidemia.
Sandra Knežević, Francesca Filippi-Arriaga, Andrej Belančić, Tamara Božina, Jasenka Mršić-Pelčić, Dinko Vitezić   +5 more
doaj   +1 more source

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Journal of Pharmacy and Bioallied Sciences, 2014
Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules.
Kanika Madaan, Sandeep Kumar, Neelam Poonia, Viney Lather, Deepti Pandita   +4 more
doaj   +1 more source

Estimating the prevalence of potential and actionable drug‐gene interactions in Irish primary care: A cross‐sectional study

British Journal of Clinical Pharmacology
Pharmacogenetics (PGx) is increasingly recognized as a strategy for medicines optimisation and prevention of adverse drug reactions. According to guidelines produced by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch ...
L. Johnson, E. Youssef, J. O'Shea, T. Thornley, J. Gallagher, M. Ledwidge, C. Ryan   +6 more
semanticscholar   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

A realistic assessment of methods for extracting gene/protein interactions from free text [PDF]

, 2009
Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research.
Kabiljo, R., Clegg, AB, Renata Kabiljo, Shepherd, AJ, Kabiljo Renata, Clegg Andrew B, Andrew B Clegg, Shepherd Adrian J, Shepherd, Adrian J., Kabiljo, R, Clegg, A.B., Adrian J Shepherd   +11 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Compliance with national guidelines for the management of drug-drug interactions in Dutch community pharmacies. [PDF]

, 2007
Item does not contain fulltextBACKGROUND: Pharmacists contribute to the detection and prevention of drug therapy-related problems, including drug-drug interactions.
Schalekamp, T., Dep Farmaceutische wetenschappen, Smet, P.A.G.M. de, Population-based studies of drug treatment: from molecule to patient outcomes, Egberts, A.C.G., de Smet, A.G.M., Buurma, H.   +6 more
core   +1 more source