Results 91 to 100 of about 7,431,159 (264)

Reporting Patterns Indicative of Adverse Drug Interactions [PDF]

, 2011
Background: Adverse drug interaction surveillance in collections of Individual Case Safety Reports (ICSRs) remains underdeveloped. Most efforts to date have focused on disproportionality analysis, but the empirical support for its value is based on ...
Bate, Andrew,, Caster, Ola,, Andrew Bate, Ola Caster, Bate, Andrew, I. Ralph Edwards, Norén, Niklas,, Niklas Norén, Edwards, I. Ralph, Strandell, Johanna,, Strandell, Johanna, Edwards, I Ralph,, Johanna Strandell   +12 more
core   +1 more source

Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms [PDF]

Brazilian Journal of Pharmaceutical Sciences
Hydroxychloroquine (HCQ) is a chiral drug used to treat malaria and inflammatory diseases, available as a racemic mixture of R-and S-HCQ. This work aimed to build physiologically-based pharmacokinetic (PBPK) models to predict the pharmacokinetics (PK) of
Gabriella de Souza Gomes Ribeiro, Leandro Francisco Pippa, Fernanda de Lima Moreira, Natália Valadares de Moraes   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Zevnik, Branko, Rode, Anja, Nicole Faust, Ross, Jillian, C. Roland Wolf, Nico Scheer, Scheer, Nico, Niehaves, Sandra, Sandra Niehaves, Faust, Nicole, Branko Zevnik, Wolf, C. Roland, Jillian Ross, Anja Rode   +13 more
core   +1 more source

HCDT 2.0: A Highly Confident Drug-Target Database for Experimentally Validated Genes, RNAs, and Pathways

Scientific Data
Drug-target interactions constitute the fundamental basis for understanding drug action mechanisms and advancing therapeutic discovery. While existing drug-target databases have contributed valuable resources, they exhibit structural and functional ...
Xinying Liu, Dehua Feng, Jiaqi Chen, Tianyi Li, Xuefeng Wang, Ruijie Zhang, Jian Chen, Xingjun Cai, Huirui Han, Lei Yu, Xia Li, Bing Li, Limei Wang, Jin Li   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

GraphDTI: A robust deep learning predictor of drug-target interactions from multiple heterogeneous data

Journal of Cheminformatics, 2021
Traditional techniqueset identification, we developed GraphDTI, a robust machine learning framework integrating the molecular-level information on drugs, proteins, and binding sites with the system-level information on gene expression and protein-protein
Guannan Liu, Manali Singha, Limeng Pu, Prasanga Neupane, Joseph Feinstein, Hsiao-Chun Wu, J. Ramanujam, Michal Brylinski   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Drug-nucleic acid interactions / [PDF]

, 2001
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.Includes ...
Chaires, Jonathan B.,editor., Waring, Michael J.,editor.   +1 more
core  

MiDNE a tool for Multi-omics genes and drugs interactions discovery

Computational and Structural Biotechnology Journal
The availability of models representing molecular interactions in complex pathologies is essential for understanding their molecular setup and identifying therapeutic vulnerabilities.
Aurora Brandi, Barbara Majello, Ines Simeone, Massimiliano Romano, Michele Ceccarelli, Giovanni Scala   +5 more
doaj   +1 more source