Results 101 to 110 of about 7,431,159 (264)

Distinguishing functional amino acid covariation from background linkage disequilibrium in HIV protease and reverse transcriptase. [PDF]

PLoS ONE, 2007
Correlated amino acid mutation analysis has been widely used to infer functional interactions between different sites in a protein. However, this analysis can be confounded by important phylogenetic effects broadly classifiable as background linkage ...
Qi Wang, Christopher Lee
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Clinical relevance of drug-drug interactions : a structured assessment procedure. [PDF]

, 2005
Item does not contain fulltextINTRODUCTION: Computerised drug interaction surveillance systems (CIS) may be helpful in detecting clinically significant drug interactions. Experience with CIS reveals that they often yield alerts with questionable clinical
Flikweert, S., Langendijk, PNJ, Smits, P, le Comte, M., Brouwers, J.R.B.J., van Roon, EN; id_orcid, Roon, E.N. van, Langendijk, P.N., Kwee-Zuiderdijk, W.J.M., Brouwers, JRBJ, Flikweert, S, van Roon, E.N., van Roon, EN, Comte, M. le, le Comte, M, Kwee-Zuiderwijk, WJM, Smits, P., Kwee-Zuiderwijk, W.J., Langendijk, P.J.N.   +18 more
core   +1 more source

Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

Cell Reports, 2019
Summary: In addition to oncogene inhibition, targeting tumor suppressor deficiency could provide potential venues for precision cancer medicine. However, the full spectrum of drug vulnerability conferred by tumor suppressor loss remains unclear.
Hongyu Ding, Jie Zhao, Yanli Zhang, Jiao Yu, Mingxian Liu, Xiaoxi Li, Liang Xu, Minghui Lin, Chuan Liu, Zhengjin He, Shishuang Chen, Hai Jiang   +11 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Synthetic lethality prediction in DNA damage repair, chromatin remodeling and the cell cycle using multi-omics data from cell lines and patients.

Scientific Reports, 2023
Discovering synthetic lethal (SL) gene partners of cancer genes is an important step in developing cancer therapies. However, identification of SL interactions is challenging, due to a large number of possible gene pairs, inherent noise and confounding ...
Magda Markowska, Magdalena A. Budzinska, Anna Coenen-Stass, Senbai Kang, Ewa Kizling, Krzysztof Kolmus, Krzysztof Koras, Eike Staub, Ewa Szczurek   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Drug–gene and drug–drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial [PDF]

, 2019
Background: Tramadol and codeine are metabolized by CYP2D6 and are subject to drug-gene and drug-drug interactions. Methods: This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine while ...
Decker, Brian S., Zang, Yong, Pratt, Victoria M., Skaar, Todd C., Holmes, Ann M., Eadon, Michael T., Zhang, Yifei, Gufford, Brandon T., Dexter, Paul R., Rosenman, Marc B., Fulton, Cathy R., Desta, Zeruesenay, Callaghan, John T., Levy, Kenneth D.   +13 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source