Results 101 to 110 of about 7,761,768 (249)

Simple F Test Reveals Gene-Gene Interactions in Case-Control Studies

, 2012
Missing heritability is still a challenge for Genome Wide Association Studies (GWAS). Gene-gene interactions may partially explain this residual genetic influence and contribute broadly to complex disease.
Adebowale Adeyemo, Jie Zhou, Ao Yuan, Guanjie Chen, Amy R. Bentley, Charles N. Rotimi   +5 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Systematic discovery of drug interaction mechanisms

Molecular Systems Biology, 2015
Drug combinations are increasingly important in disease treatments, for combating drug resistance, and for elucidating fundamental relationships in cell physiology.
Guillaume Chevereau, Tobias Bollenbach
doaj   +1 more source

A realistic assessment of methods for extracting gene/protein interactions from free text [PDF]

, 2009
Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research.
Kabiljo, R., Clegg, AB, Renata Kabiljo, Shepherd, AJ, Kabiljo Renata, Clegg Andrew B, Andrew B Clegg, Shepherd Adrian J, Shepherd, Adrian J., Kabiljo, R, Clegg, A.B., Adrian J Shepherd   +11 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Global Transcriptomic Analysis of the Interactions between Phage φAbp1 and Extensively Drug-Resistant Acinetobacter baumannii

mSystems, 2019
Acinetobacter baumannii is a growing threat, although lytic bacteriophages have been shown to effectively kill A. baumannii. However, the interaction between the host and the phage has not been fully studied.
Zichen Yang, Supeng Yin, Gang Li, Jing Wang, Guangtao Huang, Bei Jiang, Bo You, Yali Gong, Cheng Zhang, Xiaoqiang Luo, Yizhi Peng, Xia Zhao   +11 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The SafePolyMed Medication Management Center

Current Directions in Biomedical Engineering
Polypharmacy is a major risk factor for adverse drug events (ADEs), particularly when drug-drug and drug- gene interactions are insufficiently considered in routine care.
Gepp Sabine C., Schera Fatima, Marok Fatima, Selzer Dominik, Rüdesheim Simeon M., Just Katja S., Mosch Romy, Swen Jesse J., Lehr Thorsten, Kiefer Stephan   +9 more
doaj   +1 more source

Graph neural networks-based prediction of drug gene association of P2X receptors in periodontal pain

Journal of Oral Biology and Craniofacial Research
The P2X7 receptor, a member of the P2X receptor family, plays a crucial role in various physiological processes, particularly pain perception. Its expression across immune, neuronal, and glial cells facilitates the release of pro-inflammatory molecules ...
Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Seyed Ali Mosaddad, Artak Heboyan   +3 more
doaj   +1 more source

Comparison of YouScript^® recommendation severity of drug-drug, drug-gene, and drug-drug-gene interaction between the Home Health Trial and another published study population [16].

, 2017
Comparison of YouScript® recommendation severity of drug-drug, drug-gene, and drug-drug-gene interaction between the Home Health Trial and another published study population [16].
Moni B. Neradilek (665948), Lindsay S. Elliott (3713125), John C. Henderson (3713134), Nicolas A. Moyer (3713131), Kristine C. Ashcraft (3713128), Ranjit K. Thirumaran (379268)   +5 more
core   +1 more source