Results 21 to 30 of about 7,431,159 (264)

Graph Neural Networks-Based Prediction of Drug Gene Interactions of RTK-VEGF4 Receptor Family in Periodontal Regeneration. [PDF]

J Clin Exp Dent
Background The RTK-VEGF4 receptor family, which includes VEGFR-1, VEGFR-2, and VEGFR-3, plays a crucial role in tissue regeneration by promoting angiogenesis, the formation of new blood vessels, and recruiting stem cells and immune cells.
Yadalam PK, Barbosa FT, Natarajan PM, Ardila CM.   +3 more
europepmc   +2 more sources

BiGvCL: bipartite graph-based cross-domain contrastive learning model for the predicting drug-gene interactions. [PDF]

Brief Bioinform
Drug-gene interactions (DGIs) influence the toxicity or ineffectiveness of the drug therapy and play an important role in elucidating drug mechanisms, predicting potential adverse effects, and facilitating precision medicine.
He S, Wang Z, Li J, Zou Q, Zhang F.
europepmc   +2 more sources

Graph Neural Network-Based Drug Gene Interactions of Wnt/β-Catenin Pathway in Bone Formation. [PDF]

Cureus
Introduction The Wnt/β-catenin pathway is crucial for bone formation and remodeling, regulating osteoblast differentiation, bone remodeling, and skeletal homeostasis.
Yadalam PK, Ramya R, Anegundi RV, Chatterjee S.   +3 more
europepmc   +2 more sources

Variational Autoencoders for Generative Drug-Gene Interactions in Periodontal Bone Resorption. [PDF]

Cureus
Introduction Periodontal bone resorption is a significant dental problem causing tooth loss and impaired oral function. It is influenced by factors such as bacterial plaque, genetic predisposition, smoking, systemic diseases, medications, hormonal ...
Yadalam PK, Ramadoss R, Anegundi RV.
europepmc   +2 more sources

Phenotypic models of drug-drug-gene interactions mediated by cytochrome drug-metabolizing enzymes

medRxiv, 2023
Genetic polymorphisms in drug metabolizing enzymes and drug–drug interactions are major sources of inadequate drug exposure and ensuing adverse effects or insufficient responses.
Viviani R, Berres J, Stingl JC.
europepmc   +2 more sources

Pharmacogenomic Drug-Gene Interactions in Geriatric Emergency Department Patients Who Sustained Falls: A Pilot Study [PDF]

Western Journal of Emergency Medicine
Introduction: Pharmacogenomic-assisted prescribing of medications uses individual genetic information to identify drug-gene interactions. We aimed to assess potential pharmacogenomic drug-gene interactions in geriatric emergency department (ED) patients ...
Richard D. Shih, Gabriella Engstrom, Abhijit S. Pandya, Gregg B. Fields, Borivoje Furht, Ali A. Danesh, Scott M. Alter, Humberto Munoz, Lisa M. Clayton, Joshua J. Solano, Timothy Buckley, Olivia Hung, Alexander Farag, Mike Wells   +13 more
doaj   +2 more sources

Lay understandings of drug-gene interactions: The right medication, the right dose, at the right time, but what are the right words? [PDF]

Clin Transl Sci, 2022
As pharmacogenomic (PGx) testing increases in popularity, lay concepts of drug‐gene interactions set the stage for shared decision making in precision medicine.
Meagher KM, Stuttgen Finn K, Curtis SH, Borucki J, Beck AT, Cheema AW, Sharp RR.   +6 more
europepmc   +2 more sources

Graph Attention Network-Based Prediction of Drug-Gene Interactions of Signal Transducer and Activator of Transcription (STAT) Receptor in Periodontal Regeneration. [PDF]

Cureus
Introduction The signal transducer and activator of transcription-1 (STAT-1) are tightly controlled signaling pathways, with induced genes acting as positive and negative regulators.
Chatterjee S, Yadalam PK.
europepmc   +2 more sources

Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review. [PDF]

Arh Hig Rada Toksikol, 2021
Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of ...
Božina N, Ganoci L, Simičević L, Gvozdanović K, Domjanović IK, Fistrek Prlić M, Križ T, Borić Bilušić A, Laganović M, Božina T.   +9 more
europepmc   +2 more sources

Unraveling the Molecular Complexity of Adenoid Cystic Carcinoma (ACC): A Comprehensive Exploration of Hub Genes, Protein-Protein Interaction (PPI) Networks, microRNA (miRNA) Involvement, and Drug-Gene Interactions (DGIs). [PDF]

Cureus
Background Adenoid cystic carcinoma (ACC) poses clinical challenges with its unique histology and potential for perineural invasion, recurrence, and distant metastases.
Karri RL, Bojji M, Rudraraju A, Mohammad AS, Kosuru V, Kalisipudi S.   +5 more
europepmc   +2 more sources