Results 31 to 40 of about 5,801,857 (300)
Drug interactions and hepatotoxicity of clopidogrel [PDF]
, 2010 Clopidogrel (Plavix¨) is an antiplatelet drug, which is clinically used in combination with aspirin to reduce cardiovascular events in patients undergoing percutaneous coronary intervention or in patients suffering from acute coronary syndromes ...
Zahno, Anja-Christina
core +1 more source
A meta-analysis assessing the prevalence of drug-drug interactions among hospitalized patients
, 2023 PurposeDrug-drug interactions (DDIs), particularly in hospitalized patients can result in adverse drug events and unfavorable health consequences. The aim of this meta-analysis is to provide up-to-date evidence on the prevalence of clinically evident ...
Aksoy, Nilay, Öztürk, Nur
core +1 more source
Nature Communications, 2018 SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 ...
Kerstin Schott +14 more
doaj +1 more source
Clinical Data on Canabinoids: Translational Research in the Treatment of Autism Spectrum Disorders
Biomedicines, 2022 Translational research made with Cannabis sativa L. and its biocompounds provides data for some targeted diseases, as also symptoms associated with Autism Spectrum Disorders (ASDs).
Laura D. Carreira +2 more
doaj +1 more source
Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj +1 more source
Potential Drug-drug Interactions in Intensive Care Units in Turkey: A Point Prevalence Study
, 2023 Objective:Drug-drug interaction (DDI) is related with complications and diminished efficacy of medications throughout the treatment process. Intensive care units (ICU) involve patients who are at elevated risk of potential drug-drug interactions (pDDI ...
Melike Şeyda Dağdelen +3 more
core +1 more source
PharmaceuticalsClinical practice entails a translation of research that assists in the use of scientific data and therapeutic evidence for the benefit of the patient. This review critically summarizes the potential impact of cannabinoids in conjunction with other drugs
Maria G. Campos +6 more
doaj +1 more source
Data-driven prediction of adverse drug reactions induced by drug-drug interactions
BMC Pharmacology and Toxicology, 2017 Background The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-development studies because most of ...
Ruifeng Liu +5 more
doaj +1 more source
Jornal Brasileiro de Nefrologia, 2014 A doenca renal cronica (DRC), considerada a grande epidemia deste milenio, tem prevalencia media de 11% nos paises desenvolvidos. Infelizmente, no Brasil ainda nao dispomos de dados definitivos sobre a prevalencia da DRC, contudo, estudo realizado em amostra de 24.248 individuos adultos, utilizando o criterio de DRC baseado em duas determinacoes da ...
openaire +2 more sources
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
doaj +1 more source