Results 31 to 40 of about 1,102,054 (309)

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

Journal of Pharmacological Sciences, 2014
.: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
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Clinical relevance of drug-drug interactions : a structured assessment procedure. [PDF]

, 2005
Item does not contain fulltextINTRODUCTION: Computerised drug interaction surveillance systems (CIS) may be helpful in detecting clinically significant drug interactions. Experience with CIS reveals that they often yield alerts with questionable clinical
Flikweert, S., Langendijk, PNJ, Smits, P, le Comte, M., Brouwers, J.R.B.J., van Roon, EN; id_orcid, Roon, E.N. van, Langendijk, P.N., Kwee-Zuiderdijk, W.J.M., Brouwers, JRBJ, Flikweert, S, van Roon, E.N., van Roon, EN, Comte, M. le, le Comte, M, Kwee-Zuiderwijk, WJM, Smits, P., Kwee-Zuiderwijk, W.J., Langendijk, P.J.N.   +18 more
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The impact of CYP2C19 genotype on phenoconversion by concomitant medication

Frontiers in Pharmacology, 2023
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong, Soukayna Boussallami, Elena Sánchez-López, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Robert Rissmann, Robert Rissmann, Jesse J. Swen, Martijn L. Manson   +11 more
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Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain

Pharmaceuticals
Clinical practice entails a translation of research that assists in the use of scientific data and therapeutic evidence for the benefit of the patient. This review critically summarizes the potential impact of cannabinoids in conjunction with other drugs
Maria G. Campos, Maria China, Mariana Cláudio, Miguel Capinha, Rita Torres, Simão Oliveira, Ana Fortuna   +6 more
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Data-driven prediction of adverse drug reactions induced by drug-drug interactions

BMC Pharmacology and Toxicology, 2017
Background The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-development studies because most of ...
Ruifeng Liu, Mohamed Diwan M. AbdulHameed, Kamal Kumar, Xueping Yu, Anders Wallqvist, Jaques Reifman   +5 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
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Herbal - Synthetic Drug Interactions

Magna Medika, 2023
Background:  Herbal medicine is currently one of the therapeutic options chosen by the community because it is considered relatively safer and has minimal side effects.
Kintoko Kintoko, Aghnia Nabila Ananda, Anisa Rifka Ridho, Annisa Camellia Makati, Asti Afrida Yanti, Dina Wahyuni, Yolanda Sajjida Maghfirah, Isnaini Isnaini   +7 more
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Drug-drug interaction

Jornal Brasileiro de Nefrologia, 2014
A doenca renal cronica (DRC), considerada a grande epidemia deste milenio, tem prevalencia media de 11% nos paises desenvolvidos. Infelizmente, no Brasil ainda nao dispomos de dados definitivos sobre a prevalencia da DRC, contudo, estudo realizado em amostra de 24.248 individuos adultos, utilizando o criterio de DRC baseado em duas determinacoes da ...
openaire   +2 more sources

Pharmacological approach to Drug and Drug-Food Interactions

, 2023
Medication interactions must be taken into consideration in order to avoid toxicities, side effects, and lower efficacy brought on by subtherapeutic drug doses.
Hasan, Fatima
core  

Drug–Drug–Gene Interactions in Cardiovascular Medicine

Pharmacogenomics and Personalized Medicine, 2022
Innocent G Asiimwe, Munir Pirmohamed The Wolfson Centre for Personalized Medicine, MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool ...
Asiimwe IG, Pirmohamed M
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