Results 71 to 80 of about 1,578,040 (262)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Index to aerial photographs of Gunnison National Forest, Colorado, and parts of Gunnison, Saguache, Hinsdale, Delta, and Montrose counties, Colorado, 1934: set Gunnison NF34

, 2022
Set incomplete. Library owns sheets 2, and 3.Index to aerial photographs of Gunnison National Forest, Colorado, and parts of Gunnison, Sugauche, Hinsdale, Delta, and Montrose counties, Colorado, taken in 1934.

core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Counting elephants from space: An analytic framework for wildlife abundance surveys in heterogeneous terrain using satellites and AI

Ecological Solutions and Evidence
Estimates for species population size (abundance) are often obtained using aerial surveys, in particular for the African savannah elephant (Loxodonta africana).
Rebecca Wilks, Stuart King, Ruth King, Michael J. Chase, Kelly Landen, Niall McCann, David R. Williams, Murray Collins   +7 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Index to aerial photographs of Boulder County, Colorado, 1969: set AIM KK

, 2022
Scale 1:20,000.Set complete.Index to aerial photographs of Boulder County, Colorado, taken in 1969.

core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Photograph: Blue Ridge Aerial Surveys, "Aerial View of Lake Anne," Undated

, 2006
Image: Photo, black and white original; 9.75" x 7.75" (24.8 cm x 19.7 cm)Undated aerial view of Lake Anne taken by Blue Ridge Aerial Surveys. In this image Lake Anne and Lake Anne Village Center can be seen towards the right side.
Blue Ridge Aerial Surveys
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Powered paragliders in biodiversity exploration Uso de paramotores para explorar la biodiversidad

Revista Mexicana de Biodiversidad, 2006
Transportation technology is key to biodiversity exploration, and innovations often provide new access to biological questions. Powered paragliders are very small powered aircraft developed for recreational use that have great potential for use by ...
Mark E. Olson
doaj