Results 121 to 130 of about 60,562 (169)

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Shen-Shuai-II-Recipe inhibits aerobic glycolysis through SIRT1 in 5/6 ablation/infarction renal failure model. [PDF]

Sci Rep
Lan T, Zhang X, Lyu X, Wu M, Wang C, Yang L.   +5 more
europepmc   +1 more source

MCT1‐mediated bidirectional propionate transport across human placental syncytiotrophoblast layer: insights from a trophoblast stem cell‐derived barrier model

The Journal of Physiology, EarlyView.
Abstract figure legend Propionate in the fetal circulation is thought to originate from fermentation of dietary fibre by the maternal gut microbiota. However, the mechanism of transplacental transport has remained unclear. Here, we measured propionate permeability using a placental barrier model generated by differentiating human placental trophoblast ...
Toshiaki Tsuchitani, Rin Midorikawa, Akari Kasuya, Saki Noguchi, Kohei Yamamoto, Tomohiro Nishimura, Hirokazu Kaji, Takeshi Hori, Masatoshi Tomi   +8 more
wiley   +1 more source

Therapeutic Strategies Targeting Aerobic Glycolysis in Cancer and Dynamic Monitoring of Associated Metabolites. [PDF]

Cells
Hu M, Zheng K, Zhang L, Kan Y, Zhao J, Chen D.   +5 more
europepmc   +1 more source

Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling

The Journal of Physiology, EarlyView.
Abstract figure legend There has been controversy about the structural (capillary) response of skeletal muscle to altered O2 status, involving decreased supply (hypoxia) or increased demand (activity). Here we demonstrate that seven days of activation of skeletal muscle by indirect electrical stimulation led to significant expansion of the capillary ...
David Hauton, Roger W.P. Kissane, James McCullagh, Stuart Egginton   +3 more
wiley   +1 more source

ZNF280A and ACRV1 enhance aerobic glycolysis and drive ovarian cancer progression via the PI3K/AKT signaling pathway. [PDF]

J Biol Chem
Zhu D, Chen P, Yu L, Gao S, Liu Y, Pan S, Li L.   +6 more
europepmc   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation. [PDF]

Front Genet
Li J, Wang N, Bi J, Guo M, Xu B, Huang G.   +5 more
europepmc   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Brain aerobic glycolysis is stable during adulthood: Direct evidence from cross-brain blood sampling in 239 healthy adults. [PDF]

J Cereb Blood Flow Metab
Duffy JS, Ainslie PN, Rasmussen P, MacLeod DB, Gibbons TD.   +4 more
europepmc   +1 more source