Results 101 to 110 of about 60,562 (169)

The efficacy and physiological bases of small muscle mass exercise in health and disease

Experimental Physiology, EarlyView.
Abstract The conventional approach to aerobic exercise prescription involves large muscle mass exercise and the manipulation of variables such as training intensity, duration and frequency to promote desired adaptations. However, during whole‐body exercise, central limitations (i.e., neural, pulmonary and/or cardiac) constrain exercise tolerance and ...
Callum G. Brownstein
wiley   +1 more source

PFKFB4 promotes M2 polarization of tumor-associated macrophages through aerobic glycolysis-mediated modification of histone H3K18 lactylation in hepatocellular carcinoma. [PDF]

Cancer Metab
Gan C, Wu D, Yuan Y, Li L, Bai J, Xu Y, Lv H.   +6 more
europepmc   +1 more source

Sex differences in the prefrontal cortex and muscle oxygenation during exercise until exhaustion in endurance‐trained individuals

Experimental Physiology, EarlyView.
Abstract figure legend During cardiopulmonary exercise testing, the decline in oxygenation in the prefrontal cortex of women is striking. This crucial brain area is directly involved in planning motor tasks. The decline is particularly pronounced at higher exercise intensities, especially after reaching the respiratory compensation point or anaerobic ...
Daniel Ramos‐López, Raúl Caulier‐Cisterna, Benjamín Díaz‐Ortiz, Cristóbal Baumann‐Biancani, Kamilo Hunger‐Abbott, Matías Herrera‐Matas, Andrés Vega‐Moraga, Vitor A. Lira, Maximiliano Espinosa‐Ramírez, Karol Ramírez‐Parada, Luigi Gabrielli‐Nervi, Hugo E. Verdejo, Felipe Contreras‐Briceño   +12 more
wiley   +1 more source

METTL3 Potentiates Corneal Allograft Rejection via Increased Pro-Inflammatory Cytokine Production and Aerobic Glycolysis. [PDF]

Invest Ophthalmol Vis Sci
Yu H, Zeng F, Qu J, Liu X, Wei C, Wei C, Gao H.   +6 more
europepmc   +1 more source

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt. [PDF]

Sci Adv
Pellon A, Sadeghi Nasab SD, Bidkhori G, Griffiths JS, Vaga S, Begum N, Blagojevic M, Sigh NK, Kotowicz NK, Uzochukwu I, Le Guennec A, Henley-Smith R, Gregson-Williams H, Clasen F, Pryce M, Karimpour N, Cook R, Anguita J, Richardson JP, Thavaraj S, Naglik JR, Shoaie S, Moyes DL.   +22 more
europepmc   +1 more source

V̇O2max$\dot V_{\rm{O_{2max}}}$‐based all‐out aerobic exercise attenuates hexosamine biosynthetic pathway activity: Metabolomic insights in mice model

Experimental Physiology, EarlyView.
Abstract Aerobic exercise enhances physiological performance by activating metabolic systems, including glucose oxidation and fat metabolism. Cellular glucose predominantly flows through glycolysis (95–98%), whereas a smaller fraction (2–5%) enters the hexosamine biosynthetic pathway (HBP), generating UDP‐N‐acetylglucosamine.
Gyumin Kang, Eui‐Cheol Shin, Jae Kyeom Kim, Young Jun Kim   +3 more
wiley   +1 more source

FGF 13 functions as a regulator of the ERK/aerobic glycolysis axis in the inflammatory state during septic lung injury. [PDF]

Nat Commun
Zhu J, Wang J, Jiang C, Wang J, Zhou J, Tong G, Wu Y, Ou Z, Ye J, Shen E, Ke A, Li F, Jiang M, Ma J, Jin L, Li X, Cong W.   +16 more
europepmc   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

AARS1-mediated AKR1B10 lactylation stabilizes an aerobic glycolysis-positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma. [PDF]

Clin Transl Med
Liu Z, Yuan J, Su S, Han J, Zeng N, Ma Y, Chen N, Lv T.   +7 more
europepmc   +1 more source