Results 91 to 100 of about 224,058 (247)

Power to see—Drivers of aerobic glycolysis in the mammalian retina: A review [PDF]

, 2020
The mammalian retina converts most glucose to lactate rather than catabolising it completely to carbon dioxide via oxidative phosphorylation, despite the availability of oxygen. This unusual metabolism is known as aerobic glycolysis or the Warburg effect.
Cameron D. Haydinger, Thaksaon Kittipassorn, Peet, D.J., Kittipassorn, T., Daniel J. Peet, Haydinger, C.D.   +5 more
core   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Cancer Management and Research, 2021
Peng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu, Linjiang Song Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s ...
Huang P, Zhu S, Liang X, Zhang Q, Luo X, Liu C, Song L   +6 more
doaj  

GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

Frontiers in Oncology, 2020
Self-sustained cell proliferation constitutes one hallmark of cancer enabled by aerobic glycolysis which is characterized by imbalanced glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) activity, named the Warburg effect.
Annika Sünderhauf, Annika Raschdorf, Maren Hicken, Heidi Schlichting, Franziska Fetzer, Ann-Kathrin Brethack, Sven Perner, Sven Perner, Claudia Kemper, Claudia Kemper, Claudia Kemper, Berhane Ghebrehiwet, Christian Sina, Christian Sina, Stefanie Derer   +14 more
doaj   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis

, 2019
Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Here, we demonstrate that tumor-associated macrophages (TAM) enhance tumor hypoxia and aerobic glycolysis in mice subcutaneous tumors and in patients with ...
Pelletier, Martin, Weissman, Irving L., Jeon, Yoon Kyung, Ju, Ji Hyeon, Cheon, Gi Jeong, Oh, Jung-Min, Kim, Bumju, Kim, Dong-Wan, Jeong, Hoibin, Tessier, Philippe, Lee, Yoon-Jin, Lee, Chan-Ju, Defrene, Joan, Chung, Seock-Jin, Chung, Doo Hyun, Gwak, Seung-Hee, Kim, Sehui, Kim, Ki Hean, Roh, Tae-Young, Park, Jong-Wan, Kim, Il Han, Jeon, Hyeongrin, Kim, Young-Eun, Bok, Seoyeon, Lee, Jae Sung, Lee, Min Sun, Ahn, G-One, Kim, Sungjee, Kim, Hak Jae, Hong, Beom-Ju, Lee, Yun-Sang, Yoo, Min Young   +31 more
core   +2 more sources

Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells

, 2013
Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. T-cell proliferation and differentiation to effector cells require increased glucose consumption, aerobic glycolysis and glutaminolysis. The effect of IDO on the above metabolic pathways was
Stefanidis, Ioannis, Pissas, G., Antoniadi, Georgia, Arampatzis, Spyridon, Antoniadi, G., Markala, D., Yiannaki, E., Pissas, Georgios, Arampatzis, S., Stefanidis, I., Eleftheriadis, T., Liakopoulos, Vassilios, Yiannaki, Efi, Liakopoulos, V., Eleftheriadis, Theodoros, Markala, Dimitra   +15 more
core   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source