Results 71 to 80 of about 60,562 (169)

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation. [PDF]

J Transl Med
Liu J, Xiao T, Huang J.
europepmc   +1 more source

Quantitative assessment of gait alterations and variability in sulky‐driven Standardbred trotters after a standardised exercise test

Equine Veterinary Journal, EarlyView.
Abstract Background Assessment of equine metabolic and locomotory responses to quantified levels of physical exercise is needed to support the creation of tailored protocols for optimal training adaptation. The locomotory response to exercise in horses is not fully understood.
Rhana Mackie Aarts, Ineke Hillie Smit, Guilherme de Camargo Ferraz, Marie Rhodin, Filipe Manuel Serra Braganca, Elin Hernlund   +5 more
wiley   +1 more source

Modulation of Aerobic Glycolysis Genes During the Progression of Retinitis Pigmentosa. [PDF]

Invest Ophthalmol Vis Sci
Adani E, Villa Vasquez SS, Lovino M, Bighinati A, Cappellino L, D'Alessandro S, Kalatzis V, Marigo V.   +7 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

SOX4 induces cisplatin resistance in cervical cancer cells by inhibiting aerobic glycolysis. [PDF]

Cell Death Discov
Sun R, Gong H, Zhao R, Lv H, Yang H, Zhu X, Qian X, Li J, Wang Q.   +8 more
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Quercetin Inhibits Orthodontic Tooth Movement-Associated Periodontitis by Regulating Macrophage Aerobic Glycolysis Through the IL-17/Hippo/YAP Axis. [PDF]

Clin Exp Dent Res
Yao F, Song Z, Wu W, Liu B, Xia R, Zhou Y, Wang W, Chen Y, Liao Z.   +8 more
europepmc   +1 more source

Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism

The FEBS Journal, EarlyView.
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley   +1 more source

Aerobic glycolysis-driven lactate accumulation and acidic tumor microenvironment in hepatocellular carcinoma: a vicious cycle promoting tumor progression. [PDF]

Front Pharmacol
Liu M, Jiao J, Zhang H, Chang Z, Wang N, Guan X, Yan R, Huang Q, Xi Q, Li X, Bao J, Yan S, Li J.   +12 more
europepmc   +1 more source