Results 71 to 80 of about 104,202 (300)

Conservative and disruptive modes of adolescent change in human brain functional connectivity [PDF]

, 2020
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and ...
Bullmore, ET, Dolan, RJ, Fonagy, P, Goodyer, IM, Jones, PB, Kitzbichler, M, Kundu, P, NSPN Consortium, ., Patel, AX, Romero-Garcia, R, Seidlitz, J, Vaghi, MM, Vasa, F, Vértes, PE, Whitaker, KJ   +14 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Glycolysis in Chronic Liver Diseases: Mechanistic Insights and Therapeutic Opportunities

Cells, 2023
Chronic liver diseases (CLDs) cover a spectrum of liver diseases, ranging from nonalcoholic fatty liver disease to liver cancer, representing a growing epidemic worldwide with high unmet medical needs.
Hengdong Qu, Junli Liu, Di Zhang, Ruoyan Xie, Lijuan Wang, Jian Hong   +5 more
doaj   +1 more source

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis [PDF]

, 2016
During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet.
Bonder, Edward M., Faller, William J., Gao, Nan, Gumucio, Deborah L., Joshi, Shilpy, Kumar, Namit, Perekatt, Ansu O., Sansom, Owen J., Srivillibhuthur, Manasa, Verzi, Michael P., Walton, Katherine D., White, Eileen, Xing, Jinchuan, Zhou, Anbo   +13 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis

Cell Reports, 2014
Fermenting glucose in the presence of enough oxygen to support respiration, known as aerobic glycolysis, is believed to maximize growth rate. We observed increasing aerobic glycolysis during exponential growth, suggesting additional physiological roles ...
Nikolai Slavov, Bogdan A. Budnik, David Schwab, Edoardo M. Airoldi, Alexander van Oudenaarden   +4 more
doaj   +1 more source

The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease [PDF]

, 2011
Commentary on: Scheckhuber CQ et al. Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan. Aging.
Auburger, Georg, Kurz, Alexander
core   +1 more source

Radiation induces aerobic glycolysis through reactive oxygen species [PDF]

Radiotherapy and Oncology, 2013
Although radiation induced reoxygenation has been thought to increase radiosensitivity, we have shown that its associated oxidative stress can have radioprotective effects, including stabilization of the transcription factor hypoxia inducible factor 1 (HIF-1).
Jim, Zhong, Narasimhan, Rajaram, David M, Brizel, Amy E, Frees, Nirmala, Ramanujam, Ines, Batinic-Haberle, Mark W, Dewhirst   +6 more
openaire   +2 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

eLife, 2017
Rapidly proliferating cells switch from oxidative phosphorylation to aerobic glycolysis plus glutaminolysis, markedly increasing glucose and glutamine catabolism.
Lindsey Araujo, Phillip Khim, Haik Mkhikian, Christie-Lynn Mortales, Michael Demetriou   +4 more
doaj   +1 more source