Results 61 to 70 of about 224,058 (247)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

Cellular & Molecular Immunology, 2021
AbstractIn 2011, Hanahan and Weinberg added “Deregulating Cellular Energetics” and “Avoiding Immune Destruction” to the six previous hallmarks of cancer. Since this seminal paper, there has been a growing consensus that these new hallmarks are not mutually exclusive but rather interdependent.
Bradley I. Reinfeld, W. Kimryn Rathmell, Tae Kon Kim, Jeffrey C. Rathmell   +3 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Brain aerobic glycolysis functions and Alzheimer’s disease [PDF]

Clinical and Translational Imaging, 2014
Genetic, biochemical, pathological, and biomarker data demonstrate that Alzheimer's disease (AD) pathology, including the initiation and progressive buildup of insoluble forms of beta-amyloid (Aβ), appears to begin ~ 10-15 years prior to the onset of cognitive decline associated with AD.
Andrei G, Vlassenko, Marcus E, Raichle
openaire   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

DataSheet1_SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis.ZIP

, 2022
Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysis in metastatic breast cancer cells under ambient oxygen has not been well understood.
Li Su (71956), Yoshimasa Tanaka (500207), Jun Weng (8108618), Lingyun Feng (11936702), Yan Xu (14594), Wanjun Zhang (496858), Chenguang Yao (11936699), Peijing Zhang (236461)   +7 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Glycolysis in Chronic Liver Diseases: Mechanistic Insights and Therapeutic Opportunities

Cells, 2023
Chronic liver diseases (CLDs) cover a spectrum of liver diseases, ranging from nonalcoholic fatty liver disease to liver cancer, representing a growing epidemic worldwide with high unmet medical needs.
Hengdong Qu, Junli Liu, Di Zhang, Ruoyan Xie, Lijuan Wang, Jian Hong   +5 more
doaj   +1 more source

FAM129B activates Ras and promotes aerobic glycolysis [PDF]

Cell Cycle, 2016
Normal differentiated cells under normoxic conditions rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes by oxidizing glucose-derived pyr...
Jong-Ho, Lee, Haitao, Ji, Zhimin, Lu
openaire   +2 more sources

Brain aerobic glycolysis and resilience in Alzheimer disease

Proceedings of the National Academy of Sciences, 2022
The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer disease (AD). Brain AG decreases with age, but the functional significance of this decrease with regard to the development of AD symptomatology is poorly understood ...
Manu S. Goyal, Tyler Blazey, Nicholas V. Metcalf, Mark P. McAvoy, Jeremy F. Strain, Maryam Rahmani, Tony J. Durbin, Chengjie Xiong, Tammie L.-S. Benzinger, John C. Morris, Marcus E. Raichle, Andrei G. Vlassenko   +11 more
openaire   +3 more sources