Results 61 to 70 of about 104,202 (300)

The roles of glycolysis in osteosarcoma

Frontiers in Pharmacology, 2022
Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis, and treatment.
Zuxi Feng, Yanghuan Ou, Liang Hao
doaj   +1 more source

Obesity Promotes Aerobic Glycolysis in Prostate Cancer Cells [PDF]

Nutrition and Cancer, 2014
Obesity is the leading preventable comorbidity associated with increased prostate cancer-related recurrence and mortality. Epidemiological and clinical studies indicate that a body mass index >30 is associated with increased oxidative DNA damage within the prostate gland and increased prostate cancer-related mortality.
David A, Cavazos, Matthew J, deGraffenried, Shruti A, Apte, Laura W, Bowers, Kaitlin A, Whelan, Linda A, deGraffenried   +5 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. [PDF]

, 2019
As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell ...
Alumkal, Joshi J, Fan, Sili, Fiehn, Oliver, Gao, Bei, Lue, Hui-Wen, Podolak, Jennifer, Serawat, Archana, Thomas, George V, Zhang, Ying   +8 more
core   +1 more source

RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]

, 2019
Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue, Kim, Il-man, Shen, Yan, Su, Xuan, Tang, Yaoliang, Weintraub, Neal L.   +5 more
core   +1 more source

FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma

International Journal of Oncology, 2020
Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases revealed that FOXO3a expression was ...
Dong, Zhen, Yang, Jie, Li, Lin, Tan, Li, Shi, Pengfei, Zhang, Jiayi, Zhong, Xi, Ge, Lingjun, Wu, Zonghui, Cui, Hongjuan   +9 more
openaire   +3 more sources

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

Cellular & Molecular Immunology, 2021
AbstractIn 2011, Hanahan and Weinberg added “Deregulating Cellular Energetics” and “Avoiding Immune Destruction” to the six previous hallmarks of cancer. Since this seminal paper, there has been a growing consensus that these new hallmarks are not mutually exclusive but rather interdependent.
Bradley I. Reinfeld, W. Kimryn Rathmell, Tae Kon Kim, Jeffrey C. Rathmell   +3 more
openaire   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]

, 2015
Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin, Brady, Cantley, Caputo, Carnero, Cornwall, Cuervo, Cuervo, De Strooper, Debnath, Denk, Deutsch, Dikic, Djavaheri-Mergny, Eckert, Esposito, Facchiano, Fesus, Graham, Griffin, Griffin, Ha, Han, Johansen, Johansen, Ju, Khosla, Khosla, Komatsu, Kumar, Ledesma, Lenz, Levine, Levine, Liao, Liu, Lopez-Berestein, Mazurek, Mehta, Murphy, Ortona, Ozpolat, Palmieri, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Rao, Rice, Rodolfo, Saito, Semenza, Semenza, Tavernarakis, Wang, Wang, White   +61 more
core   +2 more sources