Results 61 to 70 of about 60,562 (169)

Aerobic glycolysis in bladder cancer: research advances and targeted therapy potential. [PDF]

Front Oncol
Pan M, Tao T, Kong D, Gong H.
europepmc   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

The regulatory roles of non-coding RNAs in aerobic glycolysis and therapeutic potential in pancreatic ductal adenocarcinoma. [PDF]

Ann Med
Fan Y, Tang X, Li S, Liu S, Fang Y, Sun X, Xue Z, Niu H, Chen Y, Dai C, Ling R.   +10 more
europepmc   +1 more source

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

Cancer Science, EarlyView.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu, Gang Yu, Yuan Liu, Yu Zhou, Wei Liu, Lin Wang, Lide Liu, Yan Liu, Tiejun Pan, Zhenyu Liu, Lei Gao   +10 more
wiley   +1 more source

Role and Molecular Mechanisms of Aerobic Glycolysis in Gastrointestinal Tumors. [PDF]

J Cancer
Lei Y, Peng L, Qin Z, Luo J, Luo Y, Fan Z, Wang J, Huang S, Zhao H, Lin S, Xiang L, Luo Y.   +11 more
europepmc   +1 more source

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Exosome-Mediated Regulation of Aerobic Glycolysis in Hepatocellular Carcinoma: Mechanisms and Therapeutic Implications. [PDF]

J Hepatocell Carcinoma
Zang Y, Zhao R.
europepmc   +1 more source

Methods to Study Mitochondrial Metabolism and Homeostasis in Fission Yeast

Yeast, EarlyView.
Ferran Gómez‐Armengol, Elena Hidalgo, Montserrat Vega   +2 more
wiley   +1 more source

Ketogenic Diet and β‐Hydroxybutyrate Suppress Bladder Cancer Growth and Enhance Anti‐PD‐L1 Immunotherapy Efficacy

Cancer Science, EarlyView.
Ketogenic diet and β‐hydroxybutyrate (β‐HB) suppress bladder cancer growth through direct anti‐tumor mechanisms and enhance anti‐PD‐L1 immunotherapy efficacy. β‐HB upregulates PD‐L1 via JAK2‐STAT3 activation and remodels the tumor immune microenvironment, sensitizing tumors to immune checkpoint blockade. ABSTRACT The limited clinical efficacy of immune
Yuan Zeng, Gangli Gu, Lin Yang, Bohao Fan, Haochen Cui, Lei Yan, Zhao Liu   +6 more
wiley   +1 more source

<i>KIF18B</i> Modulates SKP2 Ubiquitination to Promote Aerobic Glycolysis and Osteosarcoma Progression. [PDF]

Int J Mol Sci
Liu H, Guo X, Lu C, Lu D.
europepmc   +1 more source