Results 51 to 60 of about 104,202 (300)
FAM129B activates Ras and promotes aerobic glycolysis [PDF]
Cell Cycle, 2016 Normal differentiated cells under normoxic conditions rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes by oxidizing glucose-derived pyr...
Jong-Ho, Lee, Haitao, Ji, Zhimin, Lu
openaire +2 more sources
Brain aerobic glycolysis and resilience in Alzheimer disease
Proceedings of the National Academy of Sciences, 2022 The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer disease (AD). Brain AG decreases with age, but the functional significance of this decrease with regard to the development of AD symptomatology is poorly understood ...
Manu S. Goyal +11 more
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Role of aerobic glycolysis in genetically engineered mouse models of cancer
BMC Biology, 2013 The propensity of cancer cells to convert high levels of glucose to lactate through aerobic glycolysis has been intensively studied in vitro, and is now understood to be a metabolic adaptation that shunts glucose carbons toward building blocks for the ...
Dang Chi V
doaj +1 more source
Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH. [PDF]
, 2020 The microbial adaptations to the respiratory burst remain poorly understood, and establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive. Here we demonstrate that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium.
Chakraborty, Sangeeta +7 more
core
Research Progress of Warburg Effect in Hepatocellular Carcinoma
Frontiers in Bioscience-LandmarkThe Warburg effect, also called aerobic glycolysis, refers to tumor cells that metabolize glucose through glycolysis even in the presence of oxygen. This rapid breakdown of glucose fuels the fast development, growth, and migration of tumor cells. Lactate,
Yanguang Yang +8 more
doaj +1 more source
Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]
, 2019 York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core +1 more source
FOXK1 and FOXK2 regulate aerobic glycolysis
Nature, 2019 Adaptation to the environment and extraction of energy are essential for survival. Some species have found niches and specialized in using a particular source of energy, whereas others-including humans and several other mammals-have developed a high degree of flexibility1.
Valentina, Sukonina +20 more
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Aerobic glycolysis tunes
The EMBO Journal, 2015 Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic reprogramming is usually considered as a downstream consequence of tumor development and oncogene activation; growing evidence indicates, however, that metabolism on its turn ...
E. Enzo +11 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Journal of Immunology Research, 2021 Mitochondrial Pyruvate Carrier 1 (MPC1), one of the rate-limiting proteins involved in glycolysis metabolism, has been demonstrated as a tumor inhibitor in several cancers.
Manzila Kuerbanjiang +6 more
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