Results 31 to 40 of about 224,058 (247)

Advances in the study of aerobic glycolytic effects in resistance to radiotherapy in malignant tumors [PDF]

PeerJ, 2023
Aerobic glycolysis is a metabolic mode of tumor cells different from normal cells that plays an important role in tumor proliferation and distant metastasis.
Yuyi Liu, Zhengfu Feng, Pingmei Zhang, Honghao Chen, Song Zhu, Xin Wang   +5 more
doaj   +2 more sources

Limits and Tradeoffs in the Control of Autocatalytic Systems [PDF]

, 2013
Despite the complexity of biological networks, we find that certain common architectures govern network structures. These architectures impose fundamental constraints on system performance and create tradeoffs that the system must balance in the face of ...
Chandra, Fiona Adriani
core   +1 more source

MicroRNA-16-1-3p Represses Breast Tumor Growth and Metastasis by Inhibiting PGK1-Mediated Warburg Effect

Frontiers in Cell and Developmental Biology, 2020
The Warburg effect (aerobic glycolysis) is a hallmark of cancer and is becoming a promising target for diagnosis and therapy. Phosphoglycerate kinase 1 (PGK1) is the first adenosine triphosphate (ATP)-generating glycolytic enzyme in the aerobic ...
Tianxing Ye, Tianxing Ye, Yingchun Liang, Deyu Zhang, Xuewu Zhang   +4 more
doaj   +1 more source

Aerobic glycolysis, motility, and cytoskeletal remodeling [PDF]

Cell Cycle, 2014
Cancer cell motility and cytoskeletal remodeling are ubiquitous processes essential in cancer progression to metastasis. The role of metabolism in driving motility processes and cytoskeletal rearrangements is not fully understood, but abnormal usage of cellular energetics is a well-documented hallmark of cancer.1 Shiraishi and colleagues now provide ...
Verdone, James E, Zarif, Jelani C, Pienta, Kenneth J   +2 more
openaire   +2 more sources

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation [PDF]

, 2011
Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells.
Matthew G. Vander Heiden, Lunt, Sophia Yunkyungkwon, Sophia Y. Lunt, Vander Heiden, Matthew G.   +3 more
core   +1 more source

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis [PDF]

, 2013
SummaryA “switch” from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation.
O'Sullivan, David, Villarino, A., Jones, Russell G., Maggi, Leonard B., O’Sullivan, D., Weber, Jason D., Chang, Chih-Hao, O’Sullivan, David, Pearce, Erika L., Weber, J., Blagih, Julianna, van der Windt, Gerritje J. W., Qiu, J., Chang, C., Curtis, Jonathan D., Maggi Jr., L., Faubert, Brandon, Huang, S., Faubert, B., Villarino, Alejandro V., Curtis, J., van der Windt, G., Pearce, E., Blagih, J., Huang, Stanley Ching-Cheng, Pearce, Edward J., Jones, R., Qiu, Jing, van der Windt, Gerritje J.W.   +28 more
core   +1 more source

The intersection between aerobic glycolysis, cerebellar neurogenesis, and medulloblastoma [PDF]

, 2016
Aerobic glycolysis supports proliferation in development and cancer through unresolved mechanisms. Aerobic glycolysis, which supports the generation of biomass, is integral to cerebellar granule neuron progenitors (CGNPs) for normal growth and is ...
Tech, Katherine
core   +1 more source

Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference

Molecular Therapy: Oncolytics, 2020
Targeting metabolic reprogramming is an emerging strategy in cancer therapy. However, clinical attempts to target metabolic reprogramming have been proved to be challenging, with metabolic heterogeneity of cancer being one of many reasons that causes ...
Ting-Chun Kuo, Kuo-Yen Huang, Shuenn-Chen Yang, Sean Wu, Wei-Chia Chung, Yih-Leong Chang, Tse-Ming Hong, Shu-Ping Wang, Hsuan-Yu Chen, Tzu-Hung Hsiao, Pan-Chyr Yang   +10 more
doaj   +1 more source

A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5

Journal of Experimental & Clinical Cancer Research, 2022
Background RNA-binding proteins (RBPs) and circular RNAs (circRNAs) play important roles in glioblastoma multiforme (GBM). Aerobic glycolysis is a metabolic characteristic of GBM.
Jian Song, Jian Zheng, Xiaobai Liu, Weiwei Dong, Chunqing Yang, Di Wang, Xuelei Ruan, Yubo Zhao, Libo Liu, Ping Wang, Mengyang Zhang, Yunhui Liu   +11 more
doaj   +1 more source

Ca2+ as the prime trigger of aerobic glycolysis in astrocytes

Cell Calcium, 2021
Astroglial aerobic glycolysis, a process during which d-glucose is converted to l-lactate, a brain fuel and signal, is regulated by the plasmalemmal receptors, including adrenergic receptors (ARs) and purinergic receptors (PRs), modulating intracellular Ca2+ and cAMP signals.
Anemari Horvat, Marko Muhič, Tina Smolič, Ena Begić, Robert Zorec, Marko Kreft, Nina Vardjan   +6 more
openaire   +3 more sources