Results 1 to 10 of about 4,366,662 (271)
Discovery of a second citric acid cycle complex [PDF]
Heliyon, 2023 Together, Nobel Prize honoured work, mathematics, physics and the laws of nature have drawn a concept of clockwise cycling carboxylic acids in Krebs’ Citric Acid Cycle. A Citric Acid Cycle complex is defined by specific substrate, product and regulation.
Dirk Roosterman, Graeme Stuart Cottrell
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Citric acid cycle and the origin of MARS. [PDF]
Trends Biochem Sci, 2013 The vertebrate multiaminoacyl tRNA synthetase complex (MARS) is an assemblage of nine aminoacyl tRNA synthetases (ARSs) and three non-synthetase scaffold proteins, aminoacyl tRNA synthetase complex-interacting multifunctional protein (AIMP)1, AIMP2, and AIMP3.
Eswarappa SM, Fox PL.
europepmc +5 more sources
Citric Acid Cycle Intermediates in Cardioprotection [PDF]
Circulation: Cardiovascular Genetics, 2014 Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus
Arash Yavari +2 more
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Heliyon, 2021 Recent studies have reported that plasma levels of tricarboxylic acid (TCA) cycle metabolites and TCA cycle-related metabolite change in patients with chronic fatigue syndrome (CFS) and in healthy humans after exercise.
Yurie Hara +3 more
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Citric Acid Cycle Genes and Nutrigenetics. [PDF]
Int J Mol SciThe citric acid cycle disruptions are implicated in the pathogenesis of chronic diseases, including diabetes, obesity, cancer, and cardiovascular conditions. Numerous publications link TCA cycle disorders to oncological, neurodegenerative, and osteoporotic diseases, and specific single-nucleotide polymorphisms have been proposed as potential markers ...
Vesnina A +3 more
europepmc +3 more sources
Transporter Engineering for Enhancing Citric Acid Production in Aspergillus niger [PDF]
Journal of FungiThe efficient industrial production of citric acid by A. niger requires overcoming the limitations of substrate uptake and citrate export on the citrate synthesis efficiency.
Jie Li +6 more
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Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle [PDF]
Nature Communications, 2018 The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern ...
Greg Springsteen +4 more
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Environmental Chemistry and EcotoxicologyThe 6-PPD quinone (6-PPDQ) is derived from 6-PPD, an antioxidant added in tires. Citric acid cycle plays a pivotal role in biochemical metabolisms. In Caenorhabditis elegans, we examined effect of 6-PPDQ exposure on citric acid cycle and the role of ...
Xin Wan, Geyu Liang, Dayong Wang
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EBioMedicine, 2017 Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology.
Stein Hallan +12 more
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Abiotic origin of the citric acid cycle intermediates. [PDF]
Proc Natl Acad Sci U S AThe molecular framework for protometabolism—chemical reactions in a prebiotic environment preceding modern metabolism—has remained unknown in evolutionary biology. Mono-, di-, and tricarboxylic acids that comprise contemporary metabolism, such as the Krebs cycle, are of particular prebiotic relevance and are theorized to predate life on Earth ...
McAnally M +6 more
europepmc +4 more sources