Results 61 to 70 of about 35,333 (231)

Study on the Boundary Layer Control of Rudder of Amphibious Aircraft

Hangkong gongcheng jinzhan, 2019
After the amphibious aircraft reduces the take-off and landing speed by increasing the lift, it is necessary to improve the rudder’s handling ability. Using the CFD numerical simulation method, a two-dimensional scheme for the boundary layer control of ...
Sun Weiping, Wen Qing, Peng Xinchun
doaj   +1 more source

Inflatable Leading Edge-Based Dynamic Stall Control considering Fluid-Structure Interaction

International Journal of Aerospace Engineering, 2020
The inflatable leading edge (ILE) is explored as a dynamic stall control concept. A fluid-structure interaction (FSI) numerical method for the elastic membrane structure is constructed based on unsteady Reynolds-averaged Navier-Stokes (URANS) and a mass ...
Shi-Long Xing, He-Yong Xu, Ming-Sheng Ma, Zheng-Yin Ye   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Optimization of Temperature Measurement Method for High-Pressure Gas Flow Standard Facility Based on Sonic Nozzle Array

Aerospace
To improve the accuracy of the wind tunnel test, relying on the high-pressure gas source of the China Aerodynamic Research and Development Center, a secondary flow standard facility based on a sonic nozzle array was developed, with a pressure range of (1~
Zhihao Zhang, Jiaxi Zhao, Tingting Liu, Rongping Zhang   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Research on multi-objective optimization design for high-precision turning-milling machine tool bed based on taguchi method -FEA

Scientific Reports
As a high-precision machining equipment, the turning-milling machine tool requires its bed structure the primary load-bearing component to exhibit excellent dynamic and static characteristics that significantly influence machining accuracy and efficiency.
Hongyi Wu, Haozhen Li, Xuanyi Wang, Junshou Yang, Runze Jiang, Xiaolei Deng, Jianchen Wang   +6 more
doaj   +1 more source

Side force control on slender body by self-excited oscillation flag

Theoretical and Applied Mechanics Letters, 2016
Strong asymmetrical vortices appear on the leeward of slender body at high angles of attack, which has very unfavorable effect on the stability and control of the aircraft. A method is developed to control the side force of slender body at high angles of
Jian Zhai, Weiwei Zhang, Chuanqiang Gao, Yanhua Zhang, Zhengyin Ye, Huanling Wang   +5 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source