Results 61 to 70 of about 163,328 (242)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Assessing the impact of aerodynamic modelling on manoeuvring aircraft
, 2014 This paper investigates the impact of aerodynamic models on the dynamic response of a free-flying aircraft wing. Several options for the aerodynamics are evaluated, from two-dimensional thin aerofoil aerodynamics and unsteady vortex-lattice method up to ...
Hesse, H. +16 more
core +1 more source
Influence of wing kinematics on aerodynamic performance in hovering insect flight [PDF]
, 2007 The influence of different wing kinematic models on the aerodynamic performance of a hovering insect is investigated by means of two-dimensional time-dependent Navier–Stokes simulations.
Bijl, H. +8 more
core +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Development and evaluation of an aerodynamic model for a novel vertical axis wind turbine concept [PDF]
, 2013 There has been a resurgence of interest in the development of vertical axis wind turbines which have several inherent attributes that offer some advantages for offshore operations, particularly their scalability and low over-turning moments with better ...
Shires, A, Andrew Shires, Shires, Andrew
core +1 more source
Hangkong gongcheng jinzhan, 2020 The accelerating effect, viscous effect, and rotating effect of the propeller slipstream are of significant influences on the performance of the inlet.
WANG Limin, ZHANG Yanjun
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Unsteady flow over flexible wings at different low Reynolds numbers
EPJ Web of Conferences, 2016 In this study, unsteady flow around flexible membrane wing which had aspect ratio of 1 (AR=1) was investigated experimentally at various Reynolds numbers (Re = 25000 and Re = 50000).
Genç Mustafa Serdar +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source