Results 61 to 70 of about 1,291,837 (284)

Numerical and experimental study on aerodynamic design for the rear wing of an electric sports car

Kongqi donglixue xuebao
The rear wing is a core component determining the aerodynamic downforce of sports cars. In the design of electric sports cars, its aerodynamic development faces a fundamental contradiction: enhancing downforce to improve handling stability while ...
Kai Liu, Qiuli Luo, Junyao Wang, Qingyu Wang, Fengli Zhang, Wenjiang Wang, Rongrong Zhang   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Aerodynamic design optimization using flow feature parameterization

, 2007
Design optimization methods using high-fidelity computational fluid dynamics simulations are becoming increasingly popular in the area of aerodynamic design, sustaining the desire to make these methods more computationally efficient.
Barrett, Thomas Robin
core   +1 more source

Reliability Analysis of High-Speed Train Running on Embankment in Crosswind Environment

Applied Sciences
The aerodynamic calculation model of a high-speed train on the embankment under crosswind is built according to computational fluid dynamic (CFD) theory in order to obtain the aerodynamic forces on the train, and the running process of a high-speed train
Yunfeng Zou, Tian Zhang, Jiawei Jiao
doaj   +1 more source

Effects of surface dielectric barrier discharge on aerodynamic characteristic of train

AIP Advances, 2017
High-speed railway today has become an indispensable means of transportation due to its remarkable advantages, including comfortability, convenience and less pollution.
Lei Dong, Guoqiang Gao, Kaisheng Peng, Wenfu Wei, Chunmao Li, Guangning Wu   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Aerodynamic characteristics of a rotating sphere

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Modern ballistic models, both internal and external, are amazingly accurate. This is due in no small part to the advances in technology that reduced tolerances in the guns and provided testing equipment that provided consistent and valid results. There are few variables.
K R Crawford, N W Mitiukov, E L Busygina
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Aerodynamic noise from a train pantograph

, 2014
Many studies have shown that when the speed of high speed trains exceeds around 300km/h, aerodynamic noise becomes the most significant noise source. The pantograph, or current collector, is mounted on the top of the train and is therefore not shielded ...
Liu, Xiaowan, Hu, Zhiwei, Jurdic, Vincent, Thompson, David J.   +3 more
core   +1 more source