Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Aerodynamic characteristics in upper airways among orthodontic patients and its association with adenoid nasopharyngeal ratios in lateral cephalograms. [PDF]
BMC Med Imaging, 2021 Feng X +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Refined Simulation Methods of Fluctuating Wind and Aerodynamic Forces Relative to Moving Trains
Applied SciencesThis study proposes a framework to accurately simulate the fluctuating wind and aerodynamic forces relative to moving trains. It provides a novel method for calculating the power spectra of the fluctuating wind relative to moving trains and the time ...
Naijie Yan +5 more
doaj +1 more source
Numerical study on the influence of wall temperature gradient on aerodynamic characteristics of low aspect ratio flying wing configuration. [PDF]
Sci Rep, 2021 Lin P +6 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
MULTI-OBJECTIVE OPTIMIZATION DESIGN OF MW WIND TURBINE AIRFOILS
Jixie qiangdu, 2020 With the development of wind power generation technology,the requirements for various performances of wind turbines are higher. Aerodynamic noise problem has become a key research direction of the wind power industry.
LI YingJue, WEI KeXiang, ZHOU Zhou
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Applied SciencesIn the design of flapping-wing micro-size air vehicles capable of hovering, wings serve as the primary source of hovering power, making the analysis of aerodynamics and aerodynamic efficiency crucial.
Ruiqi Ye +4 more
doaj +1 more source
Results of tests in the MSFC 14 x 14 inch trisonic wind tunnel on a .004 scale model of the Rockwell International Space Shuttle Vehicle 3, (integrated configuration) [PDF]
Experimental aerodynamic investigations were conducted during mid-July, 1973 on a .004 scale model of the Rockwell International integrated configuration Space Shuttle Vehicle 3.
Allen, E. C., Hamiliton, T.
core +1 more source