Results 141 to 150 of about 147,888 (314)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Transonic transport study: Structures and aerodynamics [PDF]

open access: yes
The structural and aerodynamic aspects of a general study of advanced transonic transports are presented. Aircraft designed to cruise at Mach numbers of 0.90, 0.98, and 1.15 were comparatively analyzed.
Ardema, M. D., Williams, L. J.
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Influence of electrostatic water-repellent coating of the propeller blades on its aerodynamic characteristics

open access: yesМашинобудування
DOI: https://doi.org/10.26565/2079-1747-2024-34-01 The article presents approaches to the development of a methodology for improving the main aerodynamic characteristics of fixed and variable pitch propellers. The aim of the work is to improve the main
Solovei I.   +5 more
doaj  

Stability and control characteristics of an air-breathing missile configuration having a forward located inlet [PDF]

open access: yes
An investigation was made to determine the aerodynamic characteristics of an airbreathing missile configuration having a forward located inlet. Control was provided by cruciform tail surfaces.
Hayes, C., Sawyer, W. C.
core   +1 more source

Multi-colored layers for visualizing aerodynamic flow effects [PDF]

open access: yes, 1991
A method is provided for visualizing aerodynamic flow effects on a test surface. First, discrete quantities of a sublimating chemical such as naphthalene are distinctively colored via appropriate dyes or paints.
Jensen, Ronald N.
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

A Comparison of the Aerodynamic Characteristics of Eight Sailwing Airfoil Sections [PDF]

open access: yes
The operational characteristics of sailwings are discussed with emphasis placed on the importance of the trailing edge cable tension. The three dimensional aerodynamic characteristics were obtained from wind tunnel tests, and the results compared to ...
Maughmer, M. D.
core   +1 more source

Aerodynamic Characteristics of HYFLEX.

open access: yesJournal of the Japan Society for Aeronautical and Space Sciences, 1997
Shigeya WATANABE   +2 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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