Results 141 to 150 of about 147,531 (294)
Aerodynamic characteristics of airplanes at high angles of attack [PDF]
An introduction to, and a broad overiew of, the aerodynamic characteristics of airplanes at high angles of attack are provided. Items include: (1) some important fundamental phenomena which determine the aerodynamic characteristics of airplanes at high ...
Chambers, J. R., Grafton, S. B.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Transonic transport study: Structures and aerodynamics [PDF]
The structural and aerodynamic aspects of a general study of advanced transonic transports are presented. Aircraft designed to cruise at Mach numbers of 0.90, 0.98, and 1.15 were comparatively analyzed.
Ardema, M. D., Williams, L. J.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Experimental aerodynamic characteristics of vehicles traveling in tubes [PDF]
A simplified theoretical model for a vehicle traveling through an unvented tube under equilibrium incompressible conditions was used to guide the test program, reduce the data, and determine the self-consistency of the results. The results were then used
Dayman, B., Jr., Kurtz, D. W.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A Tension Shell Structure for Application to Entry Vehicles [PDF]
The shape of a shell of revolution designed t o have only tensile stresses under axisymmetric aerodynamic loadings has been derived on the basis of linear membrane theory. values of circumferential tension is also given.
Anderson, Melvin S. +3 more
core +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Aerodynamic Characteristics of a Stoker Furnace with Staged Combustion: Comparison of Cold Modeling Experiments and Numerical Simulations. [PDF]
ACS Omega, 2020 Guo X +5 more
europepmc +1 more source