Results 81 to 90 of about 12,489,898 (339)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Effect of Gurney Flap Geometry on a S809 Airfoil

open access: yesInternational Journal of Aerospace Engineering, 2019
In this paper, the effect of Gurney flap shapes on wind turbine blade airfoil S809 has been studied by numerical simulation. First, the O-type grid is used in the numerical simulation. By comparing with experimental data, such as the lift force, the drag
Li-Shu Hao, Yong-Wei Gao
doaj   +1 more source

Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications [PDF]

open access: yes
Fundamental equations of aerodynamic sensitivity analysis and approximate analysis for the two dimensional thin layer Navier-Stokes equations are reviewed, and special boundary condition considerations necessary to apply these equations to isolated ...
Hou, Gene W., Taylor, Arthur C., III
core   +1 more source

The Development of an Aerodynamic Body System for the Existing Single Seat Electric Vehicle. [PDF]

open access: yes, 2018
The Report goes through the works done by the student before November 2018 for developing of an aerodynamic vehicle body shell, which includes the project background, design features, design outcomes and drawings, conclusion and ...
Ewart, Paul, Huang, Jiarui
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

The aerodynamic design of a compressor-drive turbine for use in a 75 kw automotive engine [PDF]

open access: yes
The design of a single stage axial-flow turbine with a tip diameter of 11.15 cm is presented. The design specifications are given, and the aerodynamic design procedure is described.
Mclallin, K. L., Roelke, R. J.
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

A Unified Gas Kinetic Scheme for Transport and Collision Effects in Plasma

open access: yesApplied Sciences, 2018
In this study, the Boltzmann equation with electric acceleration term is discretized and solved by the unified gas-kinetic scheme (UGKS). The charged particle transport driven by electric field is included in the electric acceleration term.
Dongxin Pan   +3 more
doaj   +1 more source

Transonic aerodynamic design experience [PDF]

open access: yes
Advancements have occurred in transonic numerical simulation that place aerodynamic performance design into a relatively well developed status. Efficient broad band operating characteristics can be reliably developed at the conceptual design level ...
Bonner, E.
core   +1 more source

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