Results 61 to 70 of about 163,941 (314)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Aerodynamic Benchmarking of the Deepwind Design [PDF]
Energy Procedia, 2015 AbstractThe aerodynamic benchmarking for the DeepWind rotor is conducted comparing different rotor geometries and solutions and keeping the comparison as fair as possible. The objective for the benchmarking is to find the most suitable configuration in order to maximize the power production and minimize the blade solicitation and the cost of energy ...
BEDON, GABRIELE +5 more
openaire +4 more sources
The aerodynamic characteristics of a family of related hovercraft shapes [PDF]
, 1967 The handling qualities of hovercraft indicate the need for a better understanding of the influence of the basic aerodynamic characteristics. This report is the first of a series in which the aerodynamic characteristics of hovercraft shapes are studied
Andrews, E. J.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Surrogate-Based Aerodynamic Design Optimization: Use of Surrogates in Aerodynamic Design Optimization [PDF]
International Conference on Aerospace Sciences and Aviation Technology, 2009 The role of optimization in various practical applications has been increasing over the years. In the field of aerodynamics, design optimization is rapidly evolving in many ways. One of the latest developments in this field is the introduction of surrogates or metamodels.
M. Ahmed, N. Qin
openaire +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Optimal design of wind turbine blades equipped with flaps [PDF]
, 2014 As a result of the significant growth of wind turbines in size, blade load control has become the main challenge for large wind turbines. Many advanced techniques have been investigated aiming at developing control devices to ease blade loading.
Maheri, Alireza, Wiratama, I. Kade
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source