Results 81 to 90 of about 46,505 (316)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Turbomachinery aerodynamic and aeromechanic design optimization using the adjoint method [PDF]

, 2008
The thesis documents the investigation of the application of the adjoint method to turbomachinery blading design optimization, with emphasis on blading aerodynamic design optimization in a multi-bladerow environment and concurrent blading aerodynamic and
Wang, Dingxi
core  

Design and aerodynamic investigation of dynamic architecture [PDF]

Innovative Infrastructure Solutions, 2016
The effect of the spacing between adjacent building floors on the wind distribution and turbulence intensity was analysed using computational fluid dynamics in this study. Five computational models were created with floor spacing ranging from 0.8 m (benchmark) to 1.6 m.
Hassam Nasarullah Chaudhry, John Kaiser Calautit, Ben Richard Hughes   +2 more
openaire   +6 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Aerodynamic Effects of Runback Ice [PDF]

, 2013
The objectives of this PhD were to investigate the aerodynamic performance effects due to runback ice accretion with particular interest on the EASA 45 minute hold case in icing conditions. The sponsors, Airbus and Cranfield University collaboratively
Parmar, Krishan
core  

Transonic aerodynamic loads modeling of X-31 aircraft

, 2012
The generation of reduced order models for computing the unsteady and nonlinear aerodynamic loads on the X-31 aircraft from pitching motions in the transonic speed range is described.
Cummings, R. M., Post, M. L., Da Ronch, A., Badcock, K. J., Ghoreyshi, M.   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Aerodynamic design optimization using flow feature parameterization

, 2007
Design optimization methods using high-fidelity computational fluid dynamics simulations are becoming increasingly popular in the area of aerodynamic design, sustaining the desire to make these methods more computationally efficient.
Barrett, Thomas Robin
core  

Assessing the impact of aerodynamic modelling on manoeuvring aircraft

, 2014
This paper investigates the impact of aerodynamic models on the dynamic response of a free-flying aircraft wing. Several options for the aerodynamics are evaluated, from two-dimensional thin aerofoil aerodynamics and unsteady vortex-lattice method up to ...
Hesse, H., Palacios, Rafael, Hesse, H, Da Ronch, Andrea, Palacios, R., Da Ronch, A., Palacios, R, McCracken, AJ, McCracken, Andrew J., Tantaroudas, N.D., Tantaroudas, ND, Badcock, Kenneth J., Da Ronch, A, Badcock, KJ, Hesse, Henrik, Badcock, K.J., McCracken, A.J.   +16 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source