Results 81 to 90 of about 1,102,632 (282)

Modeling of unsteady aerodynamic loads

, 2011
Time-accurate solutions of the Euler or Navier-Stokes equations are still nowadays a computationally expensive approach for applications where a magnitude of parameters has to be investigated. This work focuses on flight dynamics-related studies.
Cummings, R. M., McCracken, A., Da Ronch, A., Badcock, K. J., Ghoreyshi, M.   +4 more
core   +1 more source

Musculoskeletal simulation of professional ski jumpers during take-off considering aerodynamic forces. [PDF]

Front Bioeng Biotechnol, 2023
Huang Y, Jiang L, Chen X, Sun Q, Zhang X, Tan X, Du Y, Zhang F, Wang N, Su R, Qu F, Zhang G, Huo B.   +12 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Turbulence-Model Comparison for Aerodynamic-Performance Prediction of a Typical Vertical-Axis Wind-Turbine Airfoil

Energies, 2019
In this work, different turbulence models were applied to predict the performance of a DU-06-W-200 airfoil, a typical choice for vertical-axis wind turbines (VAWT).
Andrés Meana-Fernández, Jesús Manuel Fernández Oro, Katia María Argüelles Díaz, Sandra Velarde-Suárez   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparative computational analysis of drag-reducing devices for tractor-trailers [PDF]

, 2008
Constant rise in fuel price in recent times has caused manufacturers of heavy commercial vehicles (HCV) to turn to efficient aerodynamic design of trucks, wagons, tractors as well as trailers.
Malviya, Vihar, Fieldhouse, John D., Mishra, Rakesh   +2 more
core   +3 more sources

Numerical Investigation on the Mechanism of Solid Rocket Motor Instability Induced by Differences between On-Ground and In-Flight Conditions

Aerospace
A solid rocket motor (SRM) with a high aspect ratio that performs normally during ground tests may experience instability during flight. To address this issue, this study employs the pulse triggering method and the numerical approach of two-way fluid ...
Ge Wang, Chengke Li, Weiqiang Pu, Bocheng Zhou, Haiwei Yang, Zenan Yang   +5 more
doaj   +1 more source

The vibration response mechanism of a blade disk rotor system under the coupling effects of cracks and aerodynamic forces. [PDF]

Sci Rep, 2022
Yang J, Xie J, Wang T, Yang F, Chen J.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Aerodynamic Shape Optimization Using the Discrete Adjoint of the Navier-Stokes Equations: Applications Toward Complex 3D Configutations [PDF]

, 2009
Within the next few years, numerical shape optimization based on high fidelity methods is likely to play a strategic role in future aircraft design. In this context, suitable tools have to be developed for solving aerodynamic shape optimization problems,
Dwight, Richard P., Brezillon, J., Brezillon, J. (author), Dwight, R.P. (author), Dwight, R.P., Brezillon, Joël   +5 more
core   +1 more source