Results 51 to 60 of about 90,246 (309)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

New developments in rain–wind-induced vibrations of cables [PDF]

, 2010
On wet and windy days, the inclined cables of cable stayed bridges can experience large amplitude, potentially damaging oscillations known as rain-wind-induced vibration (RWIV).
Duffy, B.R., Robertson, A.C., Sullivan, J.M., Taylor, I.J., Wilson, S.   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Flight Performance and Competitive Displacement of Hummingbirds across Elevational Gradients [PDF]

, 2006
Hummingbirds, with their impressive flight ability and competitive aerial contests, make ideal candidates for applying a mechanistic approach to studying community structure.
Altshuler, Douglas L.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Assessment of Propulsion Patterns for Hybrid Wing Configuration Aircraft with Embedded Propellers

Aerospace
This study employs computational fluid dynamics (CFD) to investigate the aerodynamic performance and static stability of hybrid wing aircraft, considering the interference of counter-rotating embedded propellers. Extensive numerical verification has been
Xiaolu Wang, Changning Chen, Zhihao Jiao, Jiahao Li, Ke Zhao   +4 more
doaj   +1 more source

Numerical Simulation for Engine/Airframe Interaction Effects of the BWB300 on Aerodynamic Performances

International Journal of Aerospace Engineering, 2019
The engine/airframe interaction effects of the BWB300 on aerodynamic performances were analyzed by using the numerical simulation method. The BWB300 is a 300-seat Blended Wing Body airplane designed by the Airplane Concept Design Institute of ...
Gang Yu, Dong Li, Yue Shu, Zeyu Zhang
doaj   +1 more source

Nonlinear Modeling Study of Aerodynamic Characteristics of an X38-like Vehicle at Strong Viscous Interaction Regions

Entropy, 2022
Strong viscous interaction and multiple flow regimes exist when vehicles fly at high altitude and high Mach number conditions. The Navier–Stokes(NS) solver is no longer applicable in the above situation.
Dingwu Jiang, Pei Wang, Jin Li, Meiliang Mao   +3 more
doaj   +1 more source

Rotor-Obstacle Aerodynamic Interaction in Hovering Flight: An Experimental Survey [PDF]

, 2016
Despite the presence of a fair number of numerical and experimental works on the rotor-obstacle interaction, a systematic study of the aerodynamic phenomena involved is lacking.
Giuni, Michea, Green, Richard B., Zagaglia, Daniele   +2 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source