Results 71 to 80 of about 635,092 (276)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Influence of interference of the wing and fuselage on aerodynamic characteristics

Information systems, mechanics and control, 2018
Виконане моделювання обтікання розрахункових моделей з різними положеннями та кута встановлення крила відносно фюзеляжу. Отримані аеродинамічні характеристики, здійснено аналіз зміни несучих властивостей та критеріїв ефективності компонування, визначені максимуми аеродинамічної досконалості К.
openaire   +4 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assessing the impact of aerodynamic modelling on manoeuvring aircraft

, 2014
This paper investigates the impact of aerodynamic models on the dynamic response of a free-flying aircraft wing. Several options for the aerodynamics are evaluated, from two-dimensional thin aerofoil aerodynamics and unsteady vortex-lattice method up to ...
Hesse, H., Palacios, Rafael, Hesse, H, Da Ronch, Andrea, Palacios, R., Da Ronch, A., Palacios, R, McCracken, AJ, McCracken, Andrew J., Tantaroudas, N.D., Tantaroudas, ND, Badcock, Kenneth J., Da Ronch, A, Badcock, KJ, Hesse, Henrik, Badcock, K.J., McCracken, A.J.   +16 more
core   +1 more source

Rotor-force controller for multirotors under aerodynamic interferences

Aerospace Science and Technology
The use of multirotors for inspection tasks requires the ability to perform high-precision flights close to the environment, where aerodynamic effects appear and make control of the platform difficult. This paper presents a control solution for multirotors to deal with aerodynamic effects and other disturbances produced at a motor level.
González Morgado, Antonio, Sanchez-Cuevas, Pedro J, Heredia Benot, José Guillermo, Ollero, Anibal   +3 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Geometric Sensitivity and Performance–Flow Field Coupling in Coaxial and Staggered Rotor Systems

International Journal of Aerospace Engineering
Multirotor aerodynamic interference exerts a remarkable influence on the aerodynamic characteristics of distributed rotorcraft. It triggers complex flow structures and performance changes, whereas the inherent relationship between flow field ...
He Zhu, Yuhao Du, Huidong Chen, Hong Nie, Xiaohui Wei, Yin Yin   +5 more
doaj   +1 more source

Layout and Rotation Effect on Aerodynamic Performance of Multi-Rotor Ducted Propellers

Drones
Multi-rotor ducted propellers, which integrate the high-efficiency characteristics of ducted propellers with the layout flexibility and safety advantages of distributed propulsion, are extensively utilized in the propulsion systems of low-altitude ...
Zeyu Li, Jianghao Wu, Pengyu Zhang, Lin Wang, Long Chen, Zhengping Zou, Haiying Lin   +6 more
doaj   +1 more source