Results 51 to 60 of about 3,114 (259)

Numerical simulation of aerodynamic interference between ejected payload and the parent aircraft

RUDN Journal of Engineering Research, 2018
The purpose of this paper is to develop reliable methodology for numerical modeling of the interference between parent aircraft and ejectable payload and to investigate the influence of the interference on aerodynamic characteristics of the payload.
Leonid V Bykov, Oleg A Pashkov, Mikhail N Pravidlo, Dmitry S Yanyshev   +3 more
doaj   +1 more source

Numerical Investigation of Aerodynamic Interference in Complete Helicopter Configurations [PDF]

International Journal of Aeronautical and Space Sciences, 2011
Unsteady flow simulations of complete helicopter configurations were conducted, and the flow fields and the aerodynamic interferences between the main rotor, fuselage, and tail rotor were investigated. For these simulations, a three-dimensional flow solver based on unstructured meshes was used, coupled with an overset mesh technique to handle relative ...
Hee-Dong Lee, Dong-Ok Yu, Oh-Joon Kwon, Hee-Jung Kang   +3 more
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The characteristics and corrections of ventral support interferences in the transonic-speed wind tunnel for the blended-wing-body aircraft

Advances in Aerodynamics
For the problem of ventral support interference in a transonic-speed wind tunnel with the blended-wing-body aircraft NPU-BWB-300 installed, the numerical simulation method based on Reynolds-averaged Navier–Stokes (RANS) equations is used to study the ...
Aoxiang Qiu, Weimin Sang, Shuya Du, Bo An, Dong Li, Binqian Zhang   +5 more
doaj   +1 more source

Research on Unsteady Aerodynamic Interference for the Tiltrotor Aircraft in Hover

Hangkong gongcheng jinzhan, 2019
The high resolution numerical simulation for rotor/wing-body interaction flow-field in hover is crucial for the accurate prediction of aerodynamic performance of the tilt-rotor aircraft, and is the one of the important issues of helicopter aerodynamics ...
Sun Kaijun, Zhang Bihui, Fu Yiwei, Zhang Lian   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Aerodynamic Performance of a Quadrotor MAV Considering the Horizontal Wind

IEEE Access, 2020
The aerodynamic performance of the quadrotor is usually suffering a lower propulsive efficiency in a windy environment. Especially the horizontal wind may affect the attitude control to provide sufficient thrust to lift the entire vehicle or cause extra ...
Yao Lei, Hengda Wang
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Aerodynamic Characteristics of Road Vehicles Overtaking on Bridge Deck under Crosswinds

Advances in Civil Engineering, 2020
The aerodynamic characteristics of road vehicles in windy environments are the prerequisites for the evaluation and prediction of the driving safety and stability.
Ning Chen, Hongxin Sun, Xiuyong Wang, Longwei Zhang   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source