Results 51 to 60 of about 635,092 (276)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Experimental Investigation of Aerodynamic Interaction in Non-Parallel Tandem Dual-Rotor Systems for Tiltrotor UAV

Drones
The distributed electric tilt-rotor Unmanned Aerial Vehicle (UAV) combines the vertical take-off and landing (VTOL) capability of helicopters with the high-speed cruise performance of fixed-wing aircraft, offering a transformative solution for Urban Air ...
He Zhu, Yuhao Du, Hong Nie, Zhiyang Xin, Xi Geng   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Aerodynamic Interference of Stratospheric Airship Envelope on Contra-Rotating Propellers

Drones
Contra-rotating propellers (CRPs) have promising applications in stratospheric airships. However, the aerodynamic interference caused by the airship envelope could lead to thrust loss, efficiency decrease, and even structure fatigue.
Guoquan Tao, Jizheng Zhang, Cong Xie, Long Jin, Bin Xiang, Jialin Chen   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analysis of transonic aerodynamic interference in the wing-nacelle region for a generic transport aircraft [PDF]

, 2005
This paper presents results of a numerical investigation dealing with steady and unsteady aerodynamic wing-nacelle-pylon (WNP) interference effects. In the first part of the paper the design process of the generic WIONA (Wing with Oscillating Nacelle ...
Voß, Ralph, Soda, Ante
core  

Simplified stability criteria for drone/carrier-aircraft close range flight

Hangkong gongcheng jinzhan
Both drone swarm intensive flight and drone aerial recovery involve the stability problem of drone/carrier-aircraft flight in close range interference flow field. This paper proposes an aerodynamic derivative model for drone/carrier-aircraft interference
HU Handong, WANG Wenkai, JIANG Xiong, SI Fangfang, LIU Fujun   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The characteristics and corrections of ventral support interferences in the transonic-speed wind tunnel for the blended-wing-body aircraft

Advances in Aerodynamics
For the problem of ventral support interference in a transonic-speed wind tunnel with the blended-wing-body aircraft NPU-BWB-300 installed, the numerical simulation method based on Reynolds-averaged Navier–Stokes (RANS) equations is used to study the ...
Aoxiang Qiu, Weimin Sang, Shuya Du, Bo An, Dong Li, Binqian Zhang   +5 more
doaj   +1 more source

Wing in Ground Effect over a Wavy Surface [PDF]

INCAS Bulletin, 2018
A vortex method has been used to investigate the effect of a wavy ground on the aerodynamic forces acting on a wing that flies in its proximity. The air is considered inviscid and incompressible.
Valentin Adrian Jean BUTOESCU
doaj   +1 more source