Results 31 to 40 of about 3,498,285 (189)

Aerodynamic shape optimization of an airliner elastic wing

ITM Web of Conferences, 2017
Aerodynamic shape optimization of a common airliner elastic wing is presented and compared with optimization of the same wing assuming rigid structure.
Navrátil Jan
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Aerodynamic Shape Optimization Using the Discrete Adjoint of the Navier-Stokes Equations: Applications Toward Complex 3D Configutations [PDF]

, 2009
Within the next few years, numerical shape optimization based on high fidelity methods is likely to play a strategic role in future aircraft design. In this context, suitable tools have to be developed for solving aerodynamic shape optimization problems,
Dwight, Richard P., Brezillon, J., Brezillon, J. (author), Dwight, R.P. (author), Dwight, R.P., Brezillon, Joël   +5 more
core   +1 more source

Optimization and Experimental Investigation of a Single-Actuation Compliant Morphing Trailing Edge for Multiple Aerodynamic Configurations

Actuators
This work presents a low-fidelity optimization method for a compliant morphing wing trailing-edge structure, developed to achieve multiple optimized aerodynamic shapes under combined aerodynamic and control loads using a single actuation pathway ...
Martynas Lendraitis, Vaidas Lukoševičius   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A novel shape optimization method using knot insertion algorithm in B-spline and its application to transonic airfoil design [PDF]

, 2011
A new method using the cubic B-spline curves with nominal uniform knot set to parameterize the geometry is proposed to deal with shape optimization problems.
Xu, B., Sherar, P. A., Zhong, B., Thompson, Christopher P., null P. A. Sherar,   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gradient-Based Aerodynamic Optimization of an Airfoil with Morphing Leading and Trailing Edges

Applied Sciences, 2021
This article presents a gradient-based aerodynamic optimization framework and investigates optimum deformations for a transonic airfoil equipped with morphing leading and trailing edges.
Zhenkai Zhang, Alessandro De Gaspari, Sergio Ricci, Chen Song, Chao Yang   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Investigation on Adjoint Based Gradient Computations for Realistic 3d Aero-Optimization [PDF]

, 2010
A discrete adjoint method for e ciently computing gradients for aerodynamic shape op- timizations is presented. The chain itself involves an unstructured mesh Reynolds-Averaged Navier-Stokes solver, and is suitable for the optimization of complex ...
Brezillon, Joel, Caslav, Ilic, Leicht, Tobias, Widhalm, Markus   +3 more
core