Results 31 to 40 of about 2,621 (218)

Optimization and Experimental Investigation of a Single-Actuation Compliant Morphing Trailing Edge for Multiple Aerodynamic Configurations

open access: yesActuators
This work presents a low-fidelity optimization method for a compliant morphing wing trailing-edge structure, developed to achieve multiple optimized aerodynamic shapes under combined aerodynamic and control loads using a single actuation pathway ...
Martynas Lendraitis   +1 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida   +6 more
wiley   +1 more source

Gradient-Based Aerodynamic Optimization of an Airfoil with Morphing Leading and Trailing Edges

open access: yesApplied Sciences, 2021
This article presents a gradient-based aerodynamic optimization framework and investigates optimum deformations for a transonic airfoil equipped with morphing leading and trailing edges.
Zhenkai Zhang   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Rapid design method of rocket aerodynamic shape based on conditional diffusion model

open access: yesKongqi donglixue xuebao
Aerodynamic design plays a vital role in rocket design. To expedite the design process of rocket aerodynamic shapes and minimize tedious iterative optimization, this study proposes a generative rapid inverse design method for rocket aerodynamic shapes ...
Chuan Li   +5 more
doaj   +1 more source

Data Mining-Based Design Space Exploration and Optimization for Tandem Airfoils

open access: yesInternational Journal of Aerospace Engineering, 2023
The joined-wing configuration has great technical appeal for the development of next-generation SensorCraft. Research based on the simplified tandem airfoil system can improve understanding of the joined-wing configuration’s aerodynamic characteristics ...
Yayun Shi   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Efficient aerodynamic shape optimization by using unsupervised manifold learning to filter geometric features

open access: yesEngineering Applications of Computational Fluid Mechanics
Many aerodynamic shape optimization methods often focus on utilizing the end-to-end relationship between design variables and aerodynamic performance to find the optimal design, while overlooking the exploration of geometric knowledge of the shape itself.
Long Ma, Xiao-Jing Wu, Wei-Wei Zhang
doaj   +1 more source

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