Results 91 to 100 of about 121,945 (278)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Scientific ReportsIn order to investigate the acoustic oscillation characteristics of gas–liquid pintle rocket engines and elucidate the path by which spray combustion process provides energy to the combustor pressure oscillation, a LOX/GCH4 pintle engine with rectangular
Xuan Jin +3 more
doaj +1 more source
Report of the panel on dynamics and aeroelasticity [PDF]
Model scaling for flutter analysis is reviewed. Characteristics of the Langley Transonic Dynamics Tunnel (TDT) are described and several features are recommended for inclusion in the National Transonic Facility.
Houbolt, J.
core +1 more source
Interactional aerodynamics and acoustics of a hingeless coaxial helicopter with an auxiliary propeller in forward flight [PDF]
, 2008 The aerodynamics and acoustics of a generic coaxial helicopter with a stiff main rotor system and a tail- mounted propulsor are investigated using Brown's Vorticity Transport Model.
Brown, R.E. +3 more
core +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Study program of local angle-of-attack effects on vehicle dynamic response Final report [PDF]
Effects of flexible body aerodynamics on launch ...
Bradley, D., Mc Canless, G. F., Jr.
core +1 more source
Development of an unsteady aerodynamics model to improve correlation of computed blade stresses with test data [PDF]
, 1985 A reliable rotor aeroelastic analysis operational that correctly predicts the vibration levels for a helicopter is utilized to test various unsteady aerodynamics models with the objective of improving the correlation between test and theory.
Gangwani, S. T.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Calculation and uncertainty analysis method for airfoil drag coefficient considering compressibility
AIP AdvancesIn order to meet the need of evaluating the effectiveness of airfoil drag reduction design, the calculation and uncertainty analysis method for airfoil drag coefficient considering compressibility is studied.
Yufeng Du +4 more
doaj +1 more source