Results 71 to 80 of about 121,945 (278)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Some applications of the quasi vortex-lattice method in steady and unsteady aerodynamics [PDF]
The quasi vortex-lattice method is reviewed and applied to the evaluation of backwash, with applications to ground effect analysis. It is also extended to unsteady aerodynamics, with particular interest in the calculation of unsteady leading-edge suction.
Lan, C. E.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Aeroelastic modeling for the FIT (Functional Integration Technology) team F/A-18 simulation [PDF]
As part of Langley Research Center's commitment to developing multidisciplinary integration methods to improve aerospace systems, the Functional Integration Technology (FIT) team was established to perform dynamics integration research using an existing ...
Wieseman, Carol D., Zeiler, Thomas A.
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Index for aerodynamic data from the Bumblebee program [PDF]
The Bumblebee program, was designed to provide a supersonic guided missile. The aerodynamics program included a fundamental research effort in supersonic aerodynamics as well as a design task in developing both test vehicles and prototypes of tactical ...
Barnes, G. A., Cronvich, L. L.
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Dynamic loads analysis system (DYLOFLEX) summary. Volume 1: Engineering formulation [PDF]
The DYLOFLEX computer program system expands the aeroelastic cycle from that in the FLEXSTAB computer program system to include dynamic loads analyses involving active controls. Two aerodynamic options exist within DYLOFLEX. The analyst can formulate the
Clemmons, R. E. +2 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
An implicit parallel UGKS solver for flows covering various regimes
Advances in Aerodynamics, 2019 This paper presents an engineering-oriented UGKS solver package developed in China Aerodynamics Research and Development Center (CARDC). The solver is programmed in Fortran language and uses structured body-fitted mesh, aiming for predicting aerodynamic ...
Dingwu Jiang +3 more
doaj +1 more source