Results 71 to 80 of about 49,122 (277)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ground Maneuvering Target Detection and Motion Parameter Estimation Method Based on RFRT-SLVD in Airborne Radar Sensor System

Sensors
This study focuses on the key challenges in detecting and estimating motion parameters of ground maneuvering targets for airborne radar sensors. The complex unknown motion states of the ground maneuvering target, including velocity, acceleration, and ...
Lanjin Lin, Yang Zhao, Yang Yang, Dong Cao, Haibo Wang, Linyan Liu, Xing Chen   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Influence of Double-Ducted Serpentine Nozzle Configurations on the Interaction Characteristics between the External and Nozzle Flow of Aircraft

Aerospace
To clarify the influence of the serpentine nozzle configurations on the flow characteristics and aerodynamic performance of aircraft, the flow features and aerodynamic performances of the double-ducted serpentine nozzles with different aspect ratios (AR),
Jilong Zhu, Yi Zhang, Yaohua Li, Liquan Zeng, Lei Miao, Neng Xiong, Yang Tao   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Viscous Boundary Layer Mesh Adaptation Method and Its Application in High-Angle-of-Attack Separated Flows

Applied Sciences
Adjoint-based mesh adaptation method serves as an effective approach to improve the predictive accuracy of aerodynamic characteristics. However, viscous boundary layer grids often encounter issues such as hanging nodes, negative volumes, and directional ...
Pengcheng Cui, Xiaojun Wu, Jiangtao Chen, Hongyin Jia, Fan Qin, Jie Zhang, Yaobing Zhang, Guiyu Zhou, Jing Tang   +8 more
doaj   +1 more source

Data processing and uncertainty evaluation method for five-hole probe considering compressibility [PDF]

AIP Advances
The data processing and uncertainty evaluation method of the five-hole probe, considering compressibility, is studied to meet the application requirements of the five-hole probe in a high-speed wind tunnel.
Yufeng Du, Lulu Wang, Qiuting Guo, Jilong Zhu, Neng Xiong   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Upwind sail aerodynamics: A RANS numerical investigation validated with wind tunnel pressure measurements [PDF]

, 2012
The aerodynamics of a sailing yacht with different sail trims are presented, derived from simulations performed using computational fluid dynamics. A Reynolds-averaged Navier-Stokes approach was used to model sixteen sail trims first tested in a wind ...
VIOLA, Ignazio, Riotte, M., Viola, I. M.; id_orcid, RIOTTE, Matthieu, Bot, P., BOT, Patrick, VIOLA, I.M   +6 more
core   +1 more source