Results 41 to 50 of about 8,560 (259)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental Investigation on Flow Control over a Circular Cylinder Using Antiphase Pulsed Jets

Actuators, 2023
To investigate the flow control characteristics of antiphase pulsed jet technology and explore a more efficient method to control unsteady flow with minimal impact on flow turbulence, wind tunnel experiments were conducted.
Jiaxin Pan, Wanbo Wang, Xunnian Wang, Chaoqun Li, Xinhai Zhao, Kun Tang   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An Efficient and Precise Hybrid Method for Mesh Deformation

Applied Sciences
Unstructured mesh deformation is an effective way to automatically generate mesh after geometric shape changes such as fluid–structure interaction simulation or aerodynamic shape optimization.
Jing Tang, Jian Zhang, Pengcheng Cui, Xiaoquan Gong, Naichun Zhou, Xie He   +5 more
doaj   +1 more source

Design of an Acoustic Synthetic Jet Actuator for Flow Control

Actuators, 2022
Synthetic jet technology is widely adopted in active flow control. An actuator with an oscillating diaphragm is a commonly used excitation device for synthetic jet generation.
Lianshan Lu, Dong Li, Zhenhui Zhang, Yin Yang, Dawei Liu, Yang Tao, Bo Lu   +6 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Ground Maneuvering Target Detection and Motion Parameter Estimation Method Based on RFRT-SLVD in Airborne Radar Sensor System

Sensors
This study focuses on the key challenges in detecting and estimating motion parameters of ground maneuvering targets for airborne radar sensors. The complex unknown motion states of the ground maneuvering target, including velocity, acceleration, and ...
Lanjin Lin, Yang Zhao, Yang Yang, Dong Cao, Haibo Wang, Linyan Liu, Xing Chen   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Influence of Double-Ducted Serpentine Nozzle Configurations on the Interaction Characteristics between the External and Nozzle Flow of Aircraft

Aerospace
To clarify the influence of the serpentine nozzle configurations on the flow characteristics and aerodynamic performance of aircraft, the flow features and aerodynamic performances of the double-ducted serpentine nozzles with different aspect ratios (AR),
Jilong Zhu, Yi Zhang, Yaohua Li, Liquan Zeng, Lei Miao, Neng Xiong, Yang Tao   +6 more
doaj   +1 more source