Results 51 to 60 of about 755,843 (383)

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

Geographic variation in the skulls of the horseshoe bats, Rhinolophus simulator and R. cf. simulator: Determining the relative contributions of adaptation and drift using geometric morphometrics

Ecology and Evolution, 2021
The relative contributions of adaptation and genetic drift to morphological diversification of the skulls of echolocating mammals were investigated using two horseshoe bat species, Rhinolophus simulator and R. cf. simulator, as test cases.
Gregory L. Mutumi, David S. Jacobs, Lunga Bam   +2 more
doaj   +1 more source

Subspace Trail Cryptanalysis and its Applications to AES

IACR Transactions on Symmetric Cryptology, 2017
We introduce subspace trail cryptanalysis, a generalization of invariant subspace cryptanalysis. With this more generic treatment of subspaces we do no longer rely on specific choices of round constants or subkeys, and the resulting method is as such a ...
Lorenzo Grassi, Christian Rechberger, Sondre Rønjom   +2 more
semanticscholar   +1 more source

A step towards digital transformation within a utility company through process automation for a sustainable energy transition

The Journal of Engineering
Sustainable energy management systems are part of the global energy transition by digitally transforming utility companies throughout the past decade. Industry 4.0 (4IR) has been adopted to improve competitiveness and align its processes with trends that
Nhora Parra, Sandra Giraldo, David laRotta, Betsy Gómez, Yissel Mejía, Laidi Morales, César Nieto‐Londoño, Rafael E. Vásquez   +7 more
doaj   +1 more source

Optimization of the symmetric encryption mode ECB dedicated to securing medical data [PDF]

Journal of Electrical and Electronics Engineering, 2021
Data security is a recurring problem to protected the private life of users, Data encryption is necessary but also delicate step to ensure at the same time speed and security of transmission and reception data, there are different models of cryptography ...
SEGHIRI Naouel, BABA-AHMED Mohammed Zakarya, BENMAMMAR Badr   +2 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

AES-CBC Software Execution Optimization

, 2012
With the proliferation of high-speed wireless networking, the necessity for efficient, robust and secure encryption modes is ever increasing. But, cryptography is primarily a computationally intensive process.
Doma, Jayramsingh, Doomun, Razvi, Tengur, Sundeep   +2 more
core   +1 more source

The price of tumor control [PDF]

, 2013
Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients.
Bergmann, Tanja, Berking, Carola, Bockmeyer, Clemens L., Dummer, Reinhard, Eigentler, Thomas, Fluck, Michael, Garbe, Claus, Goldinger, Simone M., Grabbe, Stephan, Gutzmer, Ralf, Göppner, Daniela, Hauschild, Axel, Hein, Rüdiger, Heinzerling, Lucie M., Hundorfean, Gheorghe, Justich, Armin, Kaehler, Katharina C., Keller, Ullrich, Klein, Christina, Loquai, Carmen, Mateus, Christine, Mohr, Peter, Moos, Roger von, Paetzold, Sylvie, Robert, Caroline, Satzger, Imke, Schadendorf, Dirk, Schlaeppi, Marc, Schuler, Gerold, Schuler-Thurner, Beatrice, Trefzer, Uwe, Ulrich, Jens, Vaubel, Julia, Voskens, Caroline J., Weder, Patrik, Wilhelm, Tabea   +35 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Identification of Adzuki Bean Quantitative Trait Loci Associated With Resistance to Soybean Cyst Nematode

Legume Science
Soybean cyst nematode (SCN; Heterodera glycines Ichinohe) infection has recently been shown to cause yield loss in adzuki bean (Vigna angularis [Willd.] Ohwi & Ohashi).
Chihiro Souma, Takashi Todai, Fumiko Kousaka, Hidetaka Nagasawa, Reina Ogura, Takako Suzuki   +5 more
doaj   +1 more source