Results 301 to 310 of about 12,727,021 (363)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Default mode network connectivity contributes the augment effect stress recovery by natural viewing. [PDF]

Neurobiol Stress
Chen Z, Wang C, Toulopoulou T, Chen X, Niu L, Dai H, Zhu Q, Zeng Y, Zhang R.   +8 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The role of affective states in computational psychiatry. [PDF]

Int J Neuropsychopharmacol
Benrimoh D, Smith R, Diaconescu AO, Friesen T, Jalali S, Mikus N, Gschwandtner L, Gandhi J, Horga G, Powers A.   +9 more
europepmc   +1 more source

Measurement invariance and differential item functioning of the positive and negative affect schedule: a psychometric study in Ecuadorian young adults. [PDF]

Front Psychol
Parra-Gaete C, Vinueza A, Bourgeat-Salazar M.   +2 more
europepmc   +1 more source

Context effects: discourse structure influences narrative ability in autism and first-degree relatives. [PDF]

Front Psychiatry
Landau E, Nayar K, Martin GE, Stevens C, Xing J, Guilfoyle J, Lau JCY, Losh M.   +7 more
europepmc   +1 more source

Emotional affect in heart transplant candidates: a multicenter longitudinal study. [PDF]

Front Psychol
Pennington KM, Ahmed A, Johnson BK, Yip DS, Benzo RP, Schneekloth TD, Boilson BA, Daly RC, Kennedy CC.   +8 more
europepmc   +1 more source

Clinical correlates of new-onset and persistent suicidal ideation in adolescents with major depressive disorder. [PDF]

Front Psychiatry
Zhang Y, Liu L, Fan H, Zhang X, Xia L, Liu H.   +5 more
europepmc   +1 more source