Results 51 to 60 of about 202,687 (347)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Body, ancestry, and ecstasy: reading Rotimi Fani-Kayode’s photographs in contemporary times
Vista, 2020 This article addresses different appropriations and representations of the lives of Black gay men, from the African diaspora and with transits established in late twentieth-century Europe, concerning the photographic essays of the Nigerian artist Rotimi ...
Jânderson Albino Coswosk
doaj +1 more source
“No Hatred or Malice, Fear or Affection”: Media and Sentencing
Journal of Political Economy, 2018 We explore how television broadcasting of unrelated criminal justice events affects sentencing. Exploiting as-good-as-random variation in news content before a verdict, we find that sentences are 3 months longer when the verdict is reached after coverage
Arnaud Philippe, Aurélie Ouss
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Expertise et amour dans la défense de la nature
Sociologies, 2017 Through the ethnographic study of the daily politic life of a citizen association that defends the foothills of the Andes, in Santiago, Chile, this paper describes the role of the emotional dimension in the search these citizens develop in order to ...
Consuelo Biskupovic
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Promotion of Values Education (Factors Involved in Prosocial Behaviors and Volunteering)
European Journal of Investigation in Health, Psychology and Education(1) Background: Prosocial behavior aligns with the current societal model, where human values hold greater importance considering cultural, social, and personal variables that may influence the opportunity to benefit others.
María del Carmen Olmos-Gómez +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019 Introdution: Parent-child interactive therapy is considered as an emerging approach to reduce child behavioral problems, which relies on improving parent-child relationship.
Bijan Pirnia +5 more
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