Results 141 to 150 of about 970,528 (242)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Perceived HR practices and employee performance: mediating effects of affective commitment and moderating effects of transformational leadership. [PDF]

Front Sociol
Hasinat I, Soulami M, Nassim S, Benchekroun S, Loulidi S.   +4 more
europepmc   +1 more source

Organizational affective commitment effects on militaries' well-being during a deployment: A study of a peacekeeping mission. [PDF]

Mil Psychol, 2023
Rodrigues-Silveira C, Chambel MJ, Bartone P.   +2 more
europepmc   +1 more source

Business Excellence And Organizational Commitment In Seasonal Hotels [PDF]

This paper aims to set the critical link between organizational commitment and business excellence in seasonal hotels where the seasonal staffing is the matter in service offerings.
Murat Gumus, Bahattin Hamarat
core  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The relationship between inclusive leadership in sustainable education and teachers' subjective wellbeing in Türkiye: the mediating role of affective commitment. [PDF]

Front Psychol
Çevik MN.
europepmc   +1 more source

The impact of time spent working from home on affective commitment in the workplace: The mediating role of social relationships and collective aims. [PDF]

Front Psychol, 2022
Simon AC, Aranyi G, Faragó K, Pachner OC, Kiss OE.   +4 more
europepmc   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

The impact of authentic leadership on employees' bootleg innovation behavior: the mediating role of affective commitment. [PDF]

Front Psychol
Liu W, Oubibi M, Xu Y, Li B.
europepmc   +1 more source