Results 61 to 70 of about 7,446,825 (333)

Development and validation of the Maudsley Modified Patient Health Questionnaire (MM-PHQ-9)

BJPsych Open, 2021
Background The Patient Health Questionnaire-9 (PHQ-9) is a widely used measure of depression in primary care. It was, however, originally designed as a diagnostic screening tool, and not for measuring change in response to antidepressant treatment ...
Phillippa Harrison, Syndi Walton, Diede Fennema, Suqian Duan, Tanja Jaeckle, Kimberley Goldsmith, Ewan Carr, Mark Ashworth, Allan. H. Young, Roland Zahn   +9 more
doaj   +1 more source

Affective Disorders of the State: A Spinozan Diagnosis and Cure [PDF]

, 2013
The problems of contemporary states are in large part “affective disorders”; they are failures of states to properly understand and coordinate the emotions of the individuals within and in some instances outside the state.
Tucker, Ericka L
core   +1 more source

Modeling alcohol use disorder severity: An integrative structural equation modeling approach [PDF]

, 2013
Background: Alcohol dependence is a complex psychological disorder whose phenomenology changes as the disorder progresses. Neuroscience has provided a variety of theories and evidence for the development, maintenance, and severity of addiction; however ...
Bacio, GA, Courtney, KE, Moallem, NR, Ray, LA   +3 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Emotion regulation difficulties related to depression and anxiety : a network approach to model relations among symptoms, positive reappraisal, and repetitive negative thinking [PDF]

, 2019
Frequent repetitive negative thinking and infrequent positive reappraisal use are theorized to increase risk for depression and anxiety. Yet, research has studied these regulatory strategies at the disorder level, ignoring the clinical heterogeneity and ...
Everaert, Jonas, Joormann, Jutta
core   +2 more sources

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

Oxidative Medicine and Cellular Longevity, 2016
The correlation between the affective disorders and the almost ubiquitous pathological oxidative stress can be described in a multifactorial way, as an important mechanism of central nervous system impairment.
I. Balmus, A. Ciobîcă, Iulia Antioch, R. Dobrin, D. Timofte   +4 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives

Translational Psychiatry
Excessive oxidative stress-generated nucleoside damage seems to play a key role in bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and is one of the putative mechanisms explaining accelerated atherosclerosis and ...
Klara Coello, Ilari Jaakko Olavi Mäkinen, Hanne Lie Kjærstad, Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Henrik Enghusen Poulsen, Maj Vinberg, Lars Vedel Kessing   +7 more
doaj   +1 more source

Psychopathology in Williams syndrome: the effect of individual differences across the lifespan [PDF]

, 2009
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability.
American Psychiatric Association, American Psychiatric Association, Helen F. Dodd, Jefferys D., Karmiloff-Smith A., Kaufman J., Melanie A. Porter, Mervis C. B., Pober B. R., Silverman W. K., Soni S., Switaj D. M., Woodcock R. W.   +12 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source