Results 71 to 80 of about 2,114,177 (304)

Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator

Redox Report
Objectives To evaluate the central role of oxidative stress in neurodegenerative diseases, and to explore its dynamic regulatory features, underlying signaling pathways, and molecular mechanisms, as well as advanced technological strategies for ...
Lan Zhang, Xinyue Zhai, Yalong Yan, Lihong Xiang, Yue Zhang, Xinying Zhou, Lianmei Cai, Zixi Tang, Yiyuan Xia   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Temperaments in psychotic and major affective disorders

, 2018
Background Assessment of affective temperaments with the extensively validated, 110-item TEMPS-A autoquestionnaire has been used to characterize patients with mood disorders, and its scores have been associated consistently with suicidal behavior.
Marco Innamorati, Amore M, Gustavo H. Vázquez, Fiorillo, A., Pompili, Maurizio, Inammorati M,, Girardi P, Lamis, D. A., Erburo, D., Xenia Gonda, Serafini, Gianluca, Innamorati, Marco, Denise Erbuto, Lamis, Dorian A., Gonda, Xenia, Serafini G, Erbuto, Denise, Fiorillo, Andrea, Amore, Mario, Forte A, Alberto Forte, Rihmer, Zoltan, Baldessarini RJ,, Erbuto D, Lamis DA, Zoltan Rihmer, Fiorillo A, Forte, A., Dorian A. Lamis, Vazquez GH,, Mario Amore, Pompili M,, Paolo Girardi, Ross J. Baldessarini, Girardi, Paolo, Baldessarini, Ross J., Forte, Alberto, Baldessarini, R. J., Maurizio Pompili, Gianluca Serafini, Vázquez, Gustavo H., Inammorati, Marco, Vazquez, Gustavo H., Andrea Fiorillo   +43 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Comparing the prodrome of schizophrenia-spectrum psychoses and affective disorders with and without psychotic features

, 2012
Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed.
Schultze-Lutter, Frauke, Schimmelmann, Benno G, Klosterkötter, Joachim, Ruhrmann, Stephan, Klosterkötter J, Schimmelmann, Benno Karl Edgar, Schimmelmann BG, Ruhrmann S, Schultze-Lutter F   +8 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Genetic approach to the study of heterogeneity of affective disorders

, 1987
In the present paper we compared the results of the application of segregation analysis, under two different single major locus (SML) transmission hypotheses, a dominant one with sex effect and a recessive one, to the families of 202 probands with major ...
M. Gasperini, C. Bussoleni, E. Smeraldi, F. Macciardi, A. Orsini   +4 more
core   +1 more source

Moracin M inhibits EV71 infection primarily by blocking viral attachment to host cells

Antimicrobial Agents and Chemotherapy
The global outbreak of hand, foot, and mouth disease (HFMD), mainly caused by enterovirus A71 (EV71) and coxsackievirus A16 (CA16) of the genus enterovirus, poses a serious threat to the health of young children, and severe neurological manifestations ...
Yinying Zhu, Qian Peng, Lijuan Hu, Weiling Li, Yingying Shi, Xiansheng Ye, Xiji Shu, Yuchen Liu, Wei Liu, Pin Wan, Binlian Sun   +10 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source