Results 61 to 70 of about 533,233 (349)

Development and validation of the Maudsley Modified Patient Health Questionnaire (MM-PHQ-9)

BJPsych Open, 2021
Background The Patient Health Questionnaire-9 (PHQ-9) is a widely used measure of depression in primary care. It was, however, originally designed as a diagnostic screening tool, and not for measuring change in response to antidepressant treatment ...
Phillippa Harrison, Syndi Walton, Diede Fennema, Suqian Duan, Tanja Jaeckle, Kimberley Goldsmith, Ewan Carr, Mark Ashworth, Allan. H. Young, Roland Zahn   +9 more
doaj   +1 more source

Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders [PDF]

, 2015
Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation ...
A Brown, A Demirkan, AE Green, BF Voight, CC Minica, DP Goldberg, DP Goldberg, F Samejima, F Stephenson, FF Chen, FV Rijsdijk, HM Kravitz, HW Marsh, HW Marsh, HW Marsh, HW Marsh, HW Marsh, J Liao, JC Barrett, K Hek, K Rousseau, L Hu, LE Duncan, LK Muthén, M Burmeister, M Eid, M Feyder, M Jansson, M Jeon, M Stafford, MEJ Wadsworth, NK Hansell, NR Wray, P McGuffin, P Sklar, P Sullivan, PH Lee, R Plomin, RL Jennrich, RL Jennrich, S Papiol, S Ripke, S van der Sluis, S van der Sluis, S van der Sluis, SE Medland, SP Reise, SP Reise, SP Reise, SP Reise, T Shah, U Reininghaus, U Reininghaus, V Panicker, W Feng, X Fan   +55 more
core   +6 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial

Scientific Reports, 2017
Cognitive impairments in bipolar patients deteriorate as the disorder progresses. Little is known about whether genetic risks impact cognitive recovery during the course from depression to remission.
Kangguang Lin, Guiyun Xu, Lingling Shi, Weicong Lu, Lijie Guan, Huiyi Ouyang, Kun Chen, Yamei Dang, Libing Zhou, Kwok-Fai So   +9 more
doaj   +1 more source

Neural mechanisms of affective instability and cognitive control in substance use

, 2019
Objective: We explored the impact of affect on cognitive control as this relates to individual differences in affective instability and substance use.
Bodkyn, Carmen N., Holroyd, Clay
core   +1 more source

The Clinical Features of Paranoia in the 20th Century and Their Representation in Diagnostic Criteria From DSM-III Through DSM-5 [PDF]

, 2016
This review traces, through psychiatric textbooks, the history of the Kraepelinian concept of paranoia in the 20th century and then relates the common reported symptoms and signs to the diagnostic criteria for paranoia/delusional disorder in DSM-III ...
Kendler, Kenneth S.
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effective Discussions of Affective Cases: A Survey of Attenders of the Mood Disorders Grand Rounds

BJPsych Open
Aims: Specialist mood disorder services in the UK are diverse in structure and spread over different clinical-academic centres in the UK. Relationships between these centres are strong but often based on academic projects, with limited opportunities for ...
Joseph Thorne, Tiago Costa, Michael Browning, Stuart Watson   +3 more
doaj   +1 more source

Communication Styles of Children of Mothers with Affective Disorders, Chronic Medical Illness, and Normal Controls: A Contextual Perspective

, 1993
Research has demonstrated impaired parent-child relationships in families with affective disorders. The present study examines the association of children\u27s interactional style during a direct conflict-solving task to both the mother\u27s ...
Hamilton, Elizabeth Burney, Hammen, Constance, Jones, Maren, Minasian, Gayane   +3 more
core   +1 more source