Results 101 to 110 of about 470,537 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Sadder but fitter. The evolutionary function of depressive symptoms following fetal loss [PDF]
, 2004 A literature review about an evolutionary model of fetal loss depression is presented. This model conceptualizes depression following miscarriage or stillbirth as an evolutionary protective mechanism to avoid further fetal loss.
Binser, Martin J. +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
THE SENSORY SYMPTOMS AND THE SENSORY AFFECTIONS OF THE FACIAL NERVE [PDF]
The Journal of Nervous and Mental Disease, 1907 n ...
openaire +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Longitudinal Study of Diagnoses in Children of Women With Unipolar and Bipolar Affective Disorder
, 1990 School-age children of unipolar depressed, bipolar, chronically medically ill, or normal women were diagnosed every 6 months for up to 3 years. Offspring of unipolar women had the highest rates of disorder at all evaluations, but children of bipolar and ...
Adrian, Cheri +3 more
core +1 more source
Longitudinal associations of affective symptoms with midlife cognitive function: evidence from a British birth cohort [PDF]
, 2008 Background: Affective disorders are associated with poorer cognition in older adults; however, whether this association can already be observed in midlife remains unclear.
John, Amber +5 more
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Robot Models of Mental Disorders [PDF]
, 2017 Alongside technological tools to support wellbeing and treatment of mental disorders, models of these disorders can also be invaluable tools to understand, support and improve these conditions.
Cañamero, Lola, Lewis, Matthew
core +2 more sources