Results 111 to 120 of about 470,537 (305)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Acetazolamide in the treatment of acute mania - A case report [PDF]

, 1998
Several antiepileptic drugs are also being used in affective disorders. There are some hints that also the carbonic anhydrase inhibitor acetazolamide might be useful in the treatment of bipolar affective disorder.
Brandt, C., Grunze, Heinz, Normann, C., Walden, Jörg   +3 more
core   +1 more source

The structure of affective symptoms in a sample of young adults

Comprehensive Psychiatry, 2003
Symptoms of bipolar disorders include depression and mania. The term "bipolar" implies states that are opposite to each other. Construing scales that define mania and depression as opposite ends of one dimension cannot account for the existence of mixed symptoms.
Thomas D, Meyer, Martin, Hautzinger
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Interplay between resting heart rate variability, daily affective dynamics and mental health difficulties in autistic youths

Scientific Reports
Repeated exposure to external stressors could lead to altered autonomic functioning, contributing to difficulties in emotion regulation and the development of mental health difficulties. This pathway is important to investigate in autistic youths who are
Laura Ilen, Julie Husmann, Clémence Feller, Maude Schneider   +3 more
doaj   +1 more source

Medication treatment perceptions, concerns and expectations among depressed individuals with Type I Bipolar Disorder [PDF]

, 2009
BACKGROUND: Subjective experience of illness affects outcomes among populations with bipolar disorder (BD). This cross-sectional study combined qualitative and quantitative approaches to evaluate perceived treatment effects, concerns and expectations ...
Cassidy, Kristin A, Jenkins, Janis H, Muzina, David J, Sajatovic, Martha   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Associations between degree and sub-dimensions of depression and metabolic syndrome (MetS) in the community: results from the Gutenberg Health Study (GHS)

BMC Psychiatry, 2018
Background A growing number of studies have associated metabolic syndrome (MetS) and depression, both retrospectively and prospectively. However, it has remained unclear, which degrees, or sub-dimensions of depression are related to MetS and if comorbid ...
Jörg Wiltink, Matthias Michal, Claus Jünger, Thomas Münzel, Philipp S. Wild, Karl J. Lackner, Maria Blettner, Norbert Pfeiffer, Elmar Brähler, Manfred E. Beutel   +9 more
doaj   +1 more source

Schizophrenia in older adults [PDF]

, 2011
Although the number of persons over the age of 55 with schizophrenia is expected to double over the next 20 years, the research data on older people with schizophrenia is limited.
American Psychiatric Association, Bleuler, Bleuler, Bridge, Collier, Collier, Collier, Elizabeth Collier, Jeanne M. Sorrell, Palmer, Roth, Snowden, World Health Organization   +12 more
core   +2 more sources

Physical Activity Decreases Somatic Symptom Distress in the Affect and Symptom Paradigm

Biopsychosocial Science and Medicine
Objective: According to recent empirical taxonomies (eg, the Hierarchical Taxonomy of Psychopathology), somatic symptom distress represents a transdiagnostically relevant dimension of psychopathology. To better understand the mechanisms, somatic symptoms can be experimentally provoked by inducing negative affect (in the Affect ...
Petzke, Tara M., Koeteles, Ferenc, van den Bergh, Omer, Witthoeft, Michael   +3 more
openaire   +5 more sources