Results 121 to 130 of about 3,708,183 (299)

Pacific ocean floor affects tsunami propagation: part 1

, 2014
This image shows features of the ocean floor depth (or bathymetry) from NOAA’s ETOPO-1 dataset. It shows the entire Western Pacific basin. Notice how abruptly the Japanese islands rise out of the ocean.
National Oceanic and Atmospheric Administration
core  

Game Addiction and Smartphone Dependence: Influences of Affects and Loneliness

Avances en Psicología Latinoamericana
This study examined the relationships among smartphone dependence, online game addiction, affects, and loneliness, testing affects as mediators. Participants were 459 online multiplayer gamers aged 18 to 60 years who completed measures of smartphone ...
Layrtthon Carlos de Oliveira Santos, José Ryan Lopes Cabral, Anderson Mesquita do Nascimento, Washington Allysson Dantas Silva, Tailson Evangelista Mariano, Jéssica Alves da Costa   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Excessive anterior cervical muscle tone affects hyoid bone kinetics during swallowing in healthy individuals [Corrigendum]

, 2018
Yamazaki Y, Tohara H, Hara K, Nakane A, Wakasugi Y, Yamaguchi K, Minakuchi S. Clin Interv Aging. 2017;12: 1903–1910.Page 1903, the title, “Excessive anterior cervical muscle tone affects hyoid bone kinetics during swallowing in healthy ...
Yamazaki Y, Tohara H, Wakasugi Y, Minakuchi S, Nakane A, Hara K, Yamaguchi K   +6 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

How stigmatising language affects people in Australia who use tobacco, alcohol and other drugs.

, 2020
BACKGROUND: Use of tobacco, alcohol and other drugs (TAOD) is common in Australia and can cause high morbidity and mortality. It is not uncommon for people who use TAOD to experience stigma when accessing healthcare, including general practice.
Wilson, Hester
core  

Qu'est-ce qu'un site de rencontre ?

, 2014
Il est dit depuis la création de ce blog que je travaille sur la question des politiques des affects, et ça a souvent pris le ton d'une discussion autour de la pornographie. Il est dit, bien moins souvent par contre, que je m'intéresse à la pornographie,
Fred Pailler
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source