Results 161 to 170 of about 6,895,614 (293)

From Affects to Contentious Politics.Disruptive Encounters with Migrants Along a Transalpine Route

Revue de Géographie Alpine, 2020
Cecilia Vergnano
doaj   +1 more source

Correction to "KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells". [PDF]

Dis Markers
europepmc   +1 more source

Study on the influence of intelligent human-computer interaction of AI virtual anchors on consumers' initial trust and value co-creation behavior under the technophobia. [PDF]

Front Psychol
Zhong L, Wang Y, Yue Z, Yang Y.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Calcium pyrophosphate deposition disease. [PDF]

CMAJ
Kwok TSH, Choy G.
europepmc   +1 more source

Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics.

Cell, 2017
A. García-González, Ashlyn D. Ritter, Shaleen Shrestha, Erik C. Andersen, L. Yilmaz, Albertha J. M. Walhout   +5 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Spinoza : entre anthropologie et psychologie

Astérion, 2018
Pascal Sévérac
doaj   +1 more source

ARHGAP11A affects lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD) progression by regulating FAM83A. [PDF]

Transl Cancer Res
Sun K, Song LJ, Lu RQ, Liu QZ.
europepmc   +1 more source