Results 251 to 260 of about 270,753 (338)

Methodological optimization for eliciting robust median nerve somatosensory evoked potentials for realtime single trial applications. [PDF]

J Neural Eng
Gupta D, Brangaccio J, Hill NJ.
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Does the liver talk to the brain? If so, how and why? [PDF]

PLoS Biol
Jo YH.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Feedforward extraction of behaviorally significant information by neocortical columns. [PDF]

Front Neural Circuits
Favorov OV, Kursun O.
europepmc   +1 more source

Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury

, 2018
Nobutaka Shimizu, Naoki Wada, Takahiro Shimizu, Takahisa Suzuki, Eiichiro Takaoka, Anthony Kanai, William C. de Groat, Akihide Hirayama, Mamoru Hashimoto, Hirotsugu Uemura, Naoki Yoshimura   +10 more
openalex   +2 more sources

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Adolescent stress remodels synapses in the sensory thalamus and impairs tactile discrimination in mice. [PDF]

Commun Biol
Nakayama H, Miyata M.
europepmc   +1 more source

Afferent Paresis [PDF]

, 2011
openaire   +1 more source

Visceral afferent sensitisation to bradykinin in rat jejunum in vitro: Putative role for cyclic AMP

, 1998
Alan M. Brunsden, Karen Maubach, David Grundy   +2 more
openalex   +1 more source