Results 191 to 200 of about 68,911 (310)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Neural mechanisms underlying leg muscle responses during cervical transcutaneous spinal cord stimulation. [PDF]

J Neural Eng
Phelps N, Keesey R, Hawthorn R, Atkinson C, Seáñez I.   +4 more
europepmc   +1 more source

The visual system in teleost fishes [PDF]

, 1988
Northcutt, R. G., Atema, J., Popper, A. N., Fay, R. R., Wullimann, Mario F., Tavolga, W. N.   +5 more
core   +1 more source

Oral Fine Motor Control in Patients With Anterior Maxillary Single Implants, Freestanding Teeth and Teeth Connected in 3‐Unit Bridges: An Experimental In Vivo Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives The oral fine motor control is compromised in patients with full‐arch, bimaxillary bridges compared to those with natural teeth. No previous studies have examined the differences between the prosthetic treatments small anterior bridges and single anterior implants (SI). The aim of the study was to evaluate oral fine motor control in
Nicole Winitsky, Aron Naimi‐Akbar, Jan‐Ivan Smedberg, Anastasios Grigoriadis   +3 more
wiley   +1 more source

Differentiating Afferent Lymphatic Pathways Using Dual-Dye Technique during Immediate Lymphatic Reconstruction

Plastic and Reconstructive Surgery, Global Open
Shayan M. Sarrami, MD, Meeti Mehta, BS, Carolyn De La Cruz, MD   +2 more
doaj   +1 more source

Effects of Vagal Nerve Stimulation on Rectal Tone and Distal Colon Transit in Rats Mediated via the Vagal-Sacral Pathway. [PDF]

Cells
Li Y, Wang Y, Li S, Wang K, Alam J, Gong S, Zhu Y, Chen JDZ.   +7 more
europepmc   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, EarlyView.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

On the impact of tactile processing on motor cortex: how touch shapes motor behaviour. [PDF]

Brain Struct Funct
Zafarana A, Muret D, Farnè A, Tamè L.
europepmc   +1 more source