Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Empagliflozin is renoprotective in Type 2 diabetes mellitus (T2DM). Our primary aim was to assess empagliflozin's effect on glomerular filtration rate and renal vascular resistance using multiparametric MRI (MpMRI). Our secondary aim was to assess the impact of empagliflozin on additional MpMRI‐derived metrics including markers of tissue ...
Ruth P. Lim +9 more
wiley +1 more source
Vagal sensory neurons profusely innervate the mouse gall bladder. [PDF]
Auton NeurosciNeuhuber WL +6 more
europepmc +1 more source
Diabetic Corneal Neuropathy as a Window Into Diabetic Foot Risk: A Large‐Scale Association Study
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To evaluate the association between diabetic corneal neuropathy and diabetic foot risk by examining corneal nerve features, clinical characteristics, and tear mediators in patients with different diabetic foot risk categories. Methods In this cross‐sectional study, 710 participants underwent diabetic foot examination, in vivo confocal ...
Chang Liu +12 more
wiley +1 more source
Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats
European Journal of Oral Sciences, EarlyView.Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves +7 more
wiley +1 more source
Autonomic nervous system dysfunction in irritable bowel syndrome: pathophysiology and therapeutic implications. [PDF]
Front NeurosciBai Y +5 more
europepmc +1 more source
The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation
International Endodontic Journal, EarlyView.ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli +3 more
wiley +1 more source
Fish welfare in a changing world: New developments and current challenges
Journal of Fish Biology, EarlyView.Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas +16 more
wiley +1 more source
Perspective: thermo-sensation to thermoregulation: advancing the anticipation debate via transient receptor potential (TRP) channels. [PDF]
Eur J Appl PhysiolMarino FE.
europepmc +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source